Journal of Pharmacology and Experimental Therapeutics: 371 (2)

November 01, 2019; Volume 371,Issue 2

Special Section on The Opioid Crisis

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Translating Pharmacology into Therapeutics to Fight the Opioid Crisis
Gerard J. Marek, Kathryn A. Cunningham and Kurt Rasmussen

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 394-395; DOI: https://doi.org/10.1124/jpet.119.262477
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The Opioid Crisis and the Future of Addiction and Pain Therapeutics
Nathan P. Coussens, G. Sitta Sittampalam, Samantha G. Jonson, Matthew D. Hall, Heather E. Gorby, Amir P. Tamiz, Owen B. McManus, Christian C. Felder and Kurt Rasmussen

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 396-408; DOI: https://doi.org/10.1124/jpet.119.259408
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Fighting Fire with Fire: Development of Intranasal Nalmefene to Treat Synthetic Opioid Overdose
Philip Krieter, Shwe Gyaw, Roger Crystal and Phil Skolnick

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 409-415; DOI: https://doi.org/10.1124/jpet.118.256115
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A Pragmatic Utility Function to Describe the Risk-Benefit Composite of Opioid and Nonopioid Analgesic Medication
Anne E. Olesen, Suzanne Broens, Søren S. Olesen, Marieke Niesters, Monique van Velzen, Asbjørn M. Drewes, Albert Dahan and Erik Olofsen

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 416-421; DOI: https://doi.org/10.1124/jpet.118.253716
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Non-Opioid Neurotransmitter Systems that Contribute to the Opioid Withdrawal Syndrome: A Review of Preclinical and Human Evidence
Kelly E. Dunn, Andrew S. Huhn, Cecilia L. Bergeria, Cassandra D. Gipson and Elise M. Weerts

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 422-452; DOI: https://doi.org/10.1124/jpet.119.258004
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Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis
Randy Torralva and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 453-475; DOI: https://doi.org/10.1124/jpet.119.258566
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Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat
James T. Meyer, Brian A. Sparling, William J. McCarty, Maosheng Zhang, Marcus Soto, Stephen Schneider, Hao Chen, Jonathan Roberts, Helming Tan, Thomas Kornecook, Paul S. Andrews and Charles G. Knutson

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 476-486; DOI: https://doi.org/10.1124/jpet.119.257105
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Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine
Shane W. Kaski, Allison N. White, Joshua D. Gross, Kristen R. Trexler, Kim Wix, Aubrie A. Harland, Thomas E. Prisinzano, Jeffrey Aubé, Steven G. Kinsey, Terry Kenakin, David P. Siderovski and Vincent Setola

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 487-499; DOI: https://doi.org/10.1124/jpet.118.255661
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Addressing the Opioid Crisis: Medical Student Instruction in Opioid Drug Pharmacology, Pain Management, and Substance Use Disorders
Brian M. Cox, Thomas E. Cote and Irwin Lucki

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 500-506; DOI: https://doi.org/10.1124/jpet.119.257329

Behavioral Pharmacology

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Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats
Lisa R. Gerak, Vanessa Minervini, Elizabeth Latham, Saba Ghodrati, Katherine V. Lillis, Jessica Wooden, Alex Disney, Stephen M. Husbands and Charles P. France

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 507-516; DOI: https://doi.org/10.1124/jpet.119.260331
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Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment
Sarah L. Withey, Roger D. Spealman, Jack Bergman and Carol A. Paronis

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 544-554; DOI: https://doi.org/10.1124/jpet.119.259010

Cardiovascular

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Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow
Amanda J. Stolarz, Mustafa Sarimollaoglu, John C. Marecki, Terry W. Fletcher, Ekaterina I. Galanzha, Sung W. Rhee, Vladimir P. Zharov, V. Suzanne Klimberg and Nancy J. Rusch

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 278-289; DOI: https://doi.org/10.1124/jpet.119.257592
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A Novel Orally Available Delta-5 Desaturase Inhibitor Prevents Atherosclerotic Lesions Accompanied by Changes in Fatty Acid Composition and Eicosanoid Production in ApoE Knockout Mice
Shuichi Takagahara, Hiromi Shinohara, Shigekazu Itokawa, Yoshinori Satomi, Ayumi Ando, Takeshi Yamamoto, Hideo Suzuki, Takuya Fujimoto, Kazuki Kubo and Shota Ikeda

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 290-298; DOI: https://doi.org/10.1124/jpet.119.259846
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Indigo Fruits Ingredient, Aucubin, Protects against LPS-Induced Cardiac Dysfunction in Mice
MingXia Duan, Yuan Yuan, Chen Liu, Zhulan Cai, Qingwen Xie, Tongtong Hu, Qizhu Tang and QingQing Wu

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 348-359; DOI: https://doi.org/10.1124/jpet.119.259069

Drug Discovery and Translational Medicine

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Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors
Pamela J. Farrell, Christopher J. Zopf, Huey-Jing Huang, Deepika Balakrishna, Corine Holub, James Bilakovics, Andrea Fanjul, Jennifer Matuszkiewicz, Artur Plonowski, Paul Rolzin, Urmi Banerjee, Jacques Ermolieff, Zacharia S. Cheruvallath, Christopher McBride, Darian Bartkowski, Crystal Mazur, Alok Pachori and Christopher J. Larson

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 299-308; DOI: https://doi.org/10.1124/jpet.119.259028
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In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution
Staci L. Haney, Yashpal S. Chhonker, Michelle L. Varney, Geoffrey Talmon, Lynette M. Smith, Daryl J. Murry and Sarah A. Holstein

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 327-338; DOI: https://doi.org/10.1124/jpet.119.258624
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Pharmacological Profile of JNJ-64179375: A Novel, Long-Acting Exosite-1 Thrombin Inhibitor
Zheng Huang Devine, Fuyong Du, Qiu Li, Matthew Bunce, Eilyn R. Lacy and Madhu Chintala

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 375-384; DOI: https://doi.org/10.1124/jpet.119.261032

Endocrine And Diabetes

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Oral Phenelzine Treatment Mitigates Metabolic Disturbances in Mice Fed a High-Fat Diet
Josep Mercader, Agustín G. Sabater, Sophie Le Gonidec, Pauline Decaunes, Alice Chaplin, Saioa Gómez-Zorita, Fermín I. Milagro and Christian Carpéné

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 555-566; DOI: https://doi.org/10.1124/jpet.119.259895

Gastrointestinal, Hepatic, Pulmonary, and Renal

Open Access
A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models
Joseph Kuo, Michael Bobardt, Udayan Chatterji, Patrick R. Mayo, Daniel J. Trepanier, Robert T. Foster, Philippe Gallay and Daren R. Ure

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 231-241; DOI: https://doi.org/10.1124/jpet.119.261099
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Withaferin A Improves Nonalcoholic Steatohepatitis in Mice
Daxesh P. Patel, Tingting Yan, Donghwan Kim, Henrique B. Dias, Kristopher W. Krausz, Shioko Kimura and Frank J. Gonzalez

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 360-374; DOI: https://doi.org/10.1124/jpet.119.256792

Metabolism, Transport, and Pharmacogenomics

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Direct Measurement of Kinetic Parameters of ABCG2-Dependent Transport of Natural Flavonoids Using a Fluorogenic Substrate
Michal Rozanski, Maciej Studzian and Lukasz Pulaski

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 309-319; DOI: https://doi.org/10.1124/jpet.119.261347
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CC-115, a Dual Mammalian Target of Rapamycin/DNA-Dependent Protein Kinase Inhibitor in Clinical Trial, Is a Substrate of ATP-Binding Cassette G2, a Risk Factor for CC-115 Resistance
Jenny Beebe and Jian-Ting Zhang

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 320-326; DOI: https://doi.org/10.1124/jpet.119.258392
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A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model
Michelle L. Montonye, Dan-Dan Tian, Tarana Arman, Katherine D. Lynch, Bruno Hagenbuch, Mary F. Paine and John D. Clarke

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 385-393; DOI: https://doi.org/10.1124/jpet.119.260489

Neuropharmacology

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Streptozotocin-Induced Diabetic Neuropathic Pain Is Associated with Potentiated Calcium-Permeable AMPA Receptor Activity in the Spinal Cord
Shao-Rui Chen, Jixiang Zhang, Hong Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 242-249; DOI: https://doi.org/10.1124/jpet.119.261339
Open Access
Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor
Su-Ying Cui, Ming-Xin Yang, Yong-He Zhang, Victor Zheng, Han-Ting Zhang, Mark E. Gurney, Ying Xu and James M. O’Donnell

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 250-259; DOI: https://doi.org/10.1124/jpet.119.259986
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Novel Adenosine Analog, N6-(4-Hydroxybenzyl)-Adenosine, Dampens Alcohol Drinking and Seeking Behaviors
Sa-Ik Hong, Lee Peyton, Yijuang Chern and Doo-Sup Choi

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 260-267; DOI: https://doi.org/10.1124/jpet.119.261529
Open Access
Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm
T. Lee Gilman, W. Anthony Owens, Christina M. George, Lauren Metzel, Melissa Vitela, Livia Ferreira, Melodi A. Bowman, Georgianna G. Gould, Glenn M. Toney and Lynette C. Daws

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 268-277; DOI: https://doi.org/10.1124/jpet.119.260794
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Differential Roles of Accumbal GSK3β in Cocaine versus Morphine-Induced Place Preference, U50,488H-Induced Place Aversion, and Object Memory
Xiangdang Shi, Jeffrey L. Barr, Eva von Weltin, Cassandra Wolsh and Ellen M. Unterwald

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 339-347; DOI: https://doi.org/10.1124/jpet.119.259283
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The Role of Dopamine D₃ Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens
Mei Huang, Wenqi He, Béla Kiss, Bence Farkas, Nika Adham and Herbert Y. Meltzer

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 517-525; DOI: https://doi.org/10.1124/jpet.119.259879
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GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine
Na-Ra Lee, Guangrong Zheng, Markos Leggas, Venumadhav Janganati, Justin R. Nickell, Peter A. Crooks, Michael T. Bardo and Linda P. Dwoskin

Journal of Pharmacology and Experimental Therapeutics November 2019, 371 (2) 526-543; DOI: https://doi.org/10.1124/jpet.119.258699

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Table of Contents

Special Section on The Opioid Crisis

Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Endocrine And Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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