Table of Contents

November 2009; 331 (2)

HIGHLIGHTED PAPER

  • Inflammation Gender Differences in Heart Disease Patients

    J Pharmacol Exp Ther November 2009 331:339

PERSPECTIVES IN PHARMACOLOGY

    • Liyun Wang,
    • Bronwen Martin,
    • Randall Brenneman,
    • Louis M. Luttrell,
    • and Stuart Maudsley

    Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders

    J Pharmacol Exp Ther November 2009 331:340-348; published ahead of print August 10, 2009, doi:10.1124/jpet.109.156380

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

    • Kathleen M. Gillooly,
    • Mark A. Pattoli,
    • Tracy L. Taylor,
    • Laishun Chen,
    • Lihong Cheng,
    • Kurt R. Gregor,
    • Gena S. Whitney,
    • Vojkan Susulic,
    • Scott H. Watterson,
    • James Kempson,
    • William J. Pitts,
    • Hollie Booth-Lute,
    • Guchen Yang,
    • Paul Davies,
    • Daniel W. Kukral,
    • Joann Strnad,
    • Kim W. McIntyre,
    • Celia J. Darienzo,
    • Luisa Salter-Cid,
    • Zheng Yang,
    • David B. Wang-Iverson,
    • and James R. Burke

    Periodic, Partial Inhibition of IκB Kinase β-Mediated Signaling Yields Therapeutic Benefit in Preclinical Models of Rheumatoid Arthritis

    J Pharmacol Exp Ther November 2009 331:349-360; published ahead of print August 3, 2009, doi:10.1124/jpet.109.156018
    • Thomas B. Sundberg,
    • Lara Swenson,
    • Daniel R. Wahl,
    • Anthony W. Opipari, Jr.,
    • and Gary D. Glick

    Apoptotic Signaling Activated by Modulation of the F0F1-ATPase: Implications for Selective Killing of Autoimmune Lymphocytes

    J Pharmacol Exp Ther November 2009 331:437-444; published ahead of print August 25, 2009, doi:10.1124/jpet.109.156422
    • Masaki Goto,
    • Jesse Chow,
    • Kenzo Muramoto,
    • Ken-ichi Chiba,
    • Satoshi Yamamoto,
    • Masanori Fujita,
    • Hiroshi Obaishi,
    • Kenji Tai,
    • Yoshiharu Mizui,
    • Isao Tanaka,
    • Donna Young,
    • Hua Yang,
    • Yuan J. Wang,
    • Hiroshi Shirota,
    • and Fabian Gusovsky

    E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities

    J Pharmacol Exp Ther November 2009 331:485-495; published ahead of print August 14, 2009, doi:10.1124/jpet.109.156554
    • Juan Sandoval,
    • Javier Escobar,
    • Javier Pereda,
    • Natalia Sacilotto,
    • José Luis Rodriguez,
    • Luis Sabater,
    • Luis Aparisi,
    • Luis Franco,
    • Gerardo López-Rodas,
    • and Juan Sastre

    Pentoxifylline Prevents Loss of PP2A Phosphatase Activity and Recruitment of Histone Acetyltransferases to Proinflammatory Genes in Acute Pancreatitis

    J Pharmacol Exp Ther November 2009 331:609-617; published ahead of print August 11, 2009, doi:10.1124/jpet.109.157537
    • Hideo Kohka Takahashi,
    • Keyue Liu,
    • Hidenori Wake,
    • Shuji Mori,
    • Jiyong Zhang,
    • Rui Liu,
    • Tadashi Yoshino,
    • and Masahiro Nishibori

    Prostaglandin E2 Inhibits Advanced Glycation End Product-Induced Adhesion Molecule Expression, Cytokine Production, and Lymphocyte Proliferation in Human Peripheral Blood Mononuclear Cells

    J Pharmacol Exp Ther November 2009 331:656-670; published ahead of print August 21, 2009, doi:10.1124/jpet.109.157594
    • Delphine Carbonnelle,
    • Muriel Duflos,
    • Pascal Marchand,
    • Catherine Chauvet,
    • Jean-Yves Petit,
    • and François Lang

    A Novel Indole-3-propanamide Exerts Its Immunosuppressive Activity by Inhibiting JAK3 in T Cells

    J Pharmacol Exp Ther November 2009 331:710-716; published ahead of print August 26, 2009, doi:10.1124/jpet.109.155986

NEUROPHARMACOLOGY

    • Baskaran Thyagarajan,
    • Natalia Krivitskaya,
    • Joseph G. Potian,
    • Kormakur Hognason,
    • Carmen C. Garcia,
    • and Joseph J. McArdle

    Capsaicin Protects Mouse Neuromuscular Junctions from the Neuroparalytic Effects of Botulinum Neurotoxin A

    J Pharmacol Exp Ther November 2009 331:361-371; published ahead of print August 4, 2009, doi:10.1124/jpet.109.156901
    • John R. Atack,
    • Karen A. Maubach,
    • Keith A. Wafford,
    • Desmond O'Connor,
    • A. David Rodrigues,
    • David C. Evans,
    • F. David Tattersall,
    • Mark S. Chambers,
    • Angus M. MacLeod,
    • Wai-Si Eng,
    • Christine Ryan,
    • Eric Hostetler,
    • Sandra M. Sanabria,
    • Raymond E. Gibson,
    • Stephen Krause,
    • H. Donald Burns,
    • Richard J. Hargreaves,
    • Nancy G. B. Agrawal,
    • Ruth M. McKernan,
    • M. Gail Murphy,
    • Kevin Gingrich,
    • Gerard R. Dawson,
    • Donald G. Musson,
    • and Kevin J. Petty

    In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor α5 Subtype-Selective Inverse Agonist

    J Pharmacol Exp Ther November 2009 331:470-484; published ahead of print August 24, 2009, doi:10.1124/jpet.109.157636
    • Takashi Masuko,
    • Rie Namiki,
    • Yuta Nemoto,
    • Muneharu Miyake,
    • Yasuo Kizawa,
    • Toyofumi Suzuki,
    • Keiko Kashiwagi,
    • Kazuei Igarashi,
    • and Tadashi Kusama

    Neuroprotection by Tosyl-Polyamine Derivatives through the Inhibition of Ionotropic Glutamate Receptors

    J Pharmacol Exp Ther November 2009 331:522-530; published ahead of print July 30, 2009, doi:10.1124/jpet.109.152926
    • Carrie L. Wade,
    • Lori L. Eskridge,
    • H. Oanh X. Nguyen,
    • Kelley F. Kitto,
    • Laura S. Stone,
    • George Wilcox,
    • and Carolyn A. Fairbanks

    Immunoneutralization of Agmatine Sensitizes Mice to μ-Opioid Receptor Tolerance

    J Pharmacol Exp Ther November 2009 331:539-546; published ahead of print August 14, 2009, doi:10.1124/jpet.109.155424
    • K. J. Jackson,
    • J. M. McIntosh,
    • D. H. Brunzell,
    • S. S. Sanjakdar,
    • and M. I. Damaj

    The Role of α6-Containing Nicotinic Acetylcholine Receptors in Nicotine Reward and Withdrawal

    J Pharmacol Exp Ther November 2009 331:547-554; published ahead of print July 30, 2009, doi:10.1124/jpet.109.155457
    • Marek Schwendt,
    • Angelica Rocha,
    • Ronald E. See,
    • Alejandra M. Pacchioni,
    • Jacqueline F. McGinty,
    • and Peter W. Kalivas

    Extended Methamphetamine Self-Administration in Rats Results in a Selective Reduction of Dopamine Transporter Levels in the Prefrontal Cortex and Dorsal Striatum Not Accompanied by Marked Monoaminergic Depletion

    J Pharmacol Exp Ther November 2009 331:555-562; published ahead of print July 31, 2009, doi:10.1124/jpet.109.155770
    • Steven M. Grauer,
    • Virginia L. Pulito,
    • Rachel L. Navarra,
    • Michele P. Kelly,
    • Cody Kelley,
    • Radka Graf,
    • Barbara Langen,
    • Sheree Logue,
    • Julie Brennan,
    • Lixin Jiang,
    • Erik Charych,
    • Ute Egerland,
    • Feng Liu,
    • Karen L. Marquis,
    • Michael Malamas,
    • Thorsten Hage,
    • Thomas A. Comery,
    • and Nicholas J. Brandon

    Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

    J Pharmacol Exp Ther November 2009 331:574-590; published ahead of print August 6, 2009, doi:10.1124/jpet.109.155994
    • Bin Pan,
    • Wei Wang,
    • Jonathan Z. Long,
    • Dalong Sun,
    • Cecilia J. Hillard,
    • Benjamin F. Cravatt,
    • and Qing-song Liu

    Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling

    J Pharmacol Exp Ther November 2009 331:591-597; published ahead of print August 7, 2009, doi:10.1124/jpet.109.158162
    • Robert L. Martone,
    • Hua Zhou,
    • Kevin Atchison,
    • Thomas Comery,
    • Jane Z. Xu,
    • Xinyi Huang,
    • Xioahai Gong,
    • Mei Jin,
    • Anthony Kreft,
    • Boyd Harrison,
    • Scott C. Mayer,
    • Suzan Aschmies,
    • Cathleen Gonzales,
    • Margaret M. Zaleska,
    • David R. Riddell,
    • Erik Wagner,
    • Peimin Lu,
    • Shaiu-Ching Sun,
    • June Sonnenberg-Reines,
    • Aram Oganesian,
    • Karissa Adkins,
    • Michael W. Leach,
    • David W. Clarke,
    • Donna Huryn,
    • Magid Abou-Gharbia,
    • Ronald Magolda,
    • Jonathan Bard,
    • Glen Frick,
    • Sangeeta Raje,
    • S. Bradley Forlow,
    • Carrie Balliet,
    • Michael E. Burczynski,
    • Peter H. Reinhart,
    • Hong I. Wan,
    • Menelas N. Pangalos,
    • and J. Steven Jacobsen

    Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein γ-Secretase for the Treatment of Alzheimer's Disease

    J Pharmacol Exp Ther November 2009 331:598-608; published ahead of print August 11, 2009, doi:10.1124/jpet.109.152975
    • Blaise Mathias Costa,
    • Bihua Feng,
    • Timur S. Tsintsadze,
    • Richard M. Morley,
    • Mark W. Irvine,
    • Vera Tsintsadze,
    • Natasha A. Lozovaya,
    • David E. Jane,
    • and Daniel T. Monaghan

    N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat Hippocampal CA3-CA1 Synapse

    J Pharmacol Exp Ther November 2009 331:618-626; published ahead of print August 14, 2009, doi:10.1124/jpet.109.156752
    • Annabelle R Charbit,
    • Simon Akerman,
    • and Peter J Goadsby

    Comparison of the Effects of Central and Peripheral Dopamine Receptor Activation on Evoked Firing in the Trigeminocervical Complex

    J Pharmacol Exp Ther November 2009 331:752-763; published ahead of print August 5, 2009, doi:10.1124/jpet.109.151951

TOXICOLOGY

    • S. N. Lavergne,
    • H. Wang,
    • H. E. Callan,
    • B. K. Park,
    • and D. J. Naisbitt

    “Danger” Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

    J Pharmacol Exp Ther November 2009 331:372-381; published ahead of print August 7, 2009, doi:10.1124/jpet.109.155374
    • Daniel J. Conklin,
    • Petra Haberzettl,
    • Jean-Francois Lesgards,
    • Russell A. Prough,
    • Sanjay Srivastava,
    • and Aruni Bhatnagar

    Increased Sensitivity of Glutathione S-Transferase P-Null Mice to Cyclophosphamide-Induced Urinary Bladder Toxicity

    J Pharmacol Exp Ther November 2009 331:456-469; published ahead of print August 20, 2009, doi:10.1124/jpet.109.156513

CARDIOVASCULAR

    • J. Andrew Wasserstrom,
    • Rohan Sharma,
    • Matthew J. O'Toole,
    • Jiabo Zheng,
    • James E. Kelly,
    • John Shryock,
    • Luiz Belardinelli,
    • and Gary L. Aistrup

    Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart

    J Pharmacol Exp Ther November 2009 331:382-391; published ahead of print August 12, 2009, doi:10.1124/jpet.109.156471
    • Vladimir V. Shuvaev,
    • Melpo Christofidou-Solomidou,
    • Faiz Bhora,
    • Karine Laude,
    • Hua Cai,
    • Sergei Dikalov,
    • Evguenia Arguiri,
    • Charalambos C. Solomides,
    • Steven M. Albelda,
    • David G. Harrison,
    • and Vladimir R. Muzykantov

    Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium

    J Pharmacol Exp Ther November 2009 331:404-411; published ahead of print August 19, 2009, doi:10.1124/jpet.109.156877
    • Brinda K. Rana,
    • Jennifer Wessel,
    • Vafa Mahboubi,
    • Fangwen Rao,
    • Jeannine Haeller,
    • Jiaur R. Gayen,
    • Eleazar Eskin,
    • Anne M. Valle,
    • Madhusudan Das,
    • Sushil K. Mahata,
    • Laurent Taupenot,
    • Mats Stridsberg,
    • Todd T. Talley,
    • Michael G. Ziegler,
    • Douglas W. Smith,
    • Nicholas J. Schork,
    • Daniel T. O'Connor,
    • and Palmer Taylor

    Natural Variation within the Neuronal Nicotinic Acetylcholine Receptor Cluster on Human Chromosome 15q24: Influence on Heritable Autonomic Traits in Twin Pairs

    J Pharmacol Exp Ther November 2009 331:419-428; published ahead of print August 11, 2009, doi:10.1124/jpet.109.157271
    • Francesc Jiménez-Altayó,
    • Laura Caracuel,
    • Fernando J. Pérez-Asensio,
    • Sonia Martínez-Revelles,
    • Ángel Messeguer,
    • Anna M. Planas,
    • and Elisabet Vila

    Participation of Oxidative Stress on Rat Middle Cerebral Artery Changes Induced by Focal Cerebral Ischemia: Beneficial Effects of 3,4-Dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran (CR-6)

    J Pharmacol Exp Ther November 2009 331:429-436; published ahead of print August 19, 2009, doi:10.1124/jpet.109.157131
    • Angela Amoruso,
    • Claudio Bardelli,
    • Luigia G. Fresu,
    • Alessandra Palma,
    • Matteo Vidali,
    • Valeria Ferrero,
    • Flavio Ribichini,
    • Corrado Vassanelli,
    • and Sandra Brunelleschi

    Enhanced Peroxisome Proliferator-Activated Receptor-γ Expression in Monocyte/Macrophages from Coronary Artery Disease Patients and Possible Gender Differences

    J Pharmacol Exp Ther November 2009 331:531-538; published ahead of print July 30, 2009, doi:10.1124/jpet.109.154419

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

    • Hsia-lien Lin,
    • Haoming Zhang,
    • Kathleen R. Noon,
    • and Paul F. Hollenberg

    Mechanism-Based Inactivation of CYP2B1 and Its F-Helix Mutant by Two tert-Butyl Acetylenic Compounds: Covalent Modification of Prosthetic Heme Versus Apoprotein

    J Pharmacol Exp Ther November 2009 331:392-403; published ahead of print August 21, 2009, doi:10.1124/jpet.109.158782
    • Kenneth T. Luu,
    • Eric Y. Zhang,
    • Ganesh Prasanna,
    • Cathie Xiang,
    • Scott Anderson,
    • Jay Fortner,
    • and Paolo Vicini

    Pharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure-Lowering Effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl}thiophene-2-carboxylate (PF-04475270)

    J Pharmacol Exp Ther November 2009 331:627-635; published ahead of print August 18, 2009, doi:10.1124/jpet.109.157800
    • Karen L. White,
    • Gary Nguyen,
    • William N. Charman,
    • Glenn A. Edwards,
    • W. A. (Fried) Faassen,
    • and Christopher J. H. Porter

    Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid after Oral Administration of MU

    J Pharmacol Exp Ther November 2009 331:700-709; published ahead of print August 20, 2009, doi:10.1124/jpet.109.154542

BEHAVIORAL PHARMACOLOGY

    • Tara A. Macey,
    • Erin N. Bobeck,
    • Deborah M. Hegarty,
    • Sue A. Aicher,
    • Susan L. Ingram,
    • and Michael M. Morgan

    Extracellular Signal-Regulated Kinase 1/2 Activation Counteracts Morphine Tolerance in the Periaqueductal Gray of the Rat

    J Pharmacol Exp Ther November 2009 331:412-418; published ahead of print August 14, 2009, doi:10.1124/jpet.109.152157
    • Gregory T. Collins,
    • Remy L. Brim,
    • Diwahar Narasimhan,
    • Mei-Chuan Ko,
    • Roger K. Sunahara,
    • Chang-Guo Zhan,
    • and James H. Woods

    Cocaine Esterase Prevents Cocaine-Induced Toxicity and the Ongoing Intravenous Self-Administration of Cocaine in Rats

    J Pharmacol Exp Ther November 2009 331:445-455; published ahead of print August 26, 2009, doi:10.1124/jpet.108.150029
    • Jun-Xu Li,
    • Alison Unzeitig,
    • Martin A. Javors,
    • Kenner C. Rice,
    • Wouter Koek,
    • and Charles P. France

    Discriminative Stimulus Effects of 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane (DOM), Ketanserin, and (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in Rats

    J Pharmacol Exp Ther November 2009 331:671-679; published ahead of print August 17, 2009, doi:10.1124/jpet.109.157560
    • Anbrin Masood,
    • Ying Huang,
    • Hassan Hajjhussein,
    • Lan Xiao,
    • Hao Li,
    • Wei Wang,
    • Adel Hamza,
    • Chang-Guo Zhan,
    • and James M. O'Donnell

    Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

    J Pharmacol Exp Ther November 2009 331:690-699; published ahead of print August 14, 2009, doi:10.1124/jpet.109.156729
    • K. S. Murnane,
    • N. Murai,
    • L. L. Howell,
    • and W. E. Fantegrossi

    Discriminative Stimulus Effects of Psychostimulants and Hallucinogens in S(+)-3,4-Methylenedioxymethamphetamine (MDMA) and R(−)-MDMA Trained Mice

    J Pharmacol Exp Ther November 2009 331:717-723; published ahead of print August 14, 2009, doi:10.1124/jpet.109.156174

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Ole De Backer,
    • Ellen Elinck,
    • Evelien Priem,
    • Luc Leybaert,
    • and Romain A. Lefebvre

    Peroxisome Proliferator-Activated Receptor γ Activation Alleviates Postoperative Ileus in Mice by Inhibition of Egr-1 Expression and Its Downstream Target Genes

    J Pharmacol Exp Ther November 2009 331:496-503; published ahead of print August 5, 2009, doi:10.1124/jpet.109.155135
    • Anders Lehmann,
    • Madeleine Antonsson,
    • Ann Aurell Holmberg,
    • L. Ashley Blackshaw,
    • Lena Brändén,
    • Hans Bräuner-Osborne,
    • Bolette Christiansen,
    • John Dent,
    • Thomas Elebring,
    • Britt-Marie Jacobson,
    • Jörgen Jensen,
    • Jan P. Mattsson,
    • Karolina Nilsson,
    • Simo S. Oja,
    • Amanda J. Page,
    • Pirjo Saransaari,
    • and Sverker von Unge

    (R)-(3-Amino-2-fluoropropyl) Phosphinic Acid (AZD3355), a Novel GABAB Receptor Agonist, Inhibits Transient Lower Esophageal Sphincter Relaxation through a Peripheral Mode of Action

    J Pharmacol Exp Ther November 2009 331:504-512; published ahead of print July 31, 2009, doi:10.1124/jpet.109.153593

CELLULAR AND MOLECULAR

    • Samuel D. Robinson,
    • Jacqueline F. Aitken,
    • Richard J. Bailey,
    • David R. Poyner,
    • and Debbie L. Hay

    Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3

    J Pharmacol Exp Ther November 2009 331:513-521; published ahead of print July 30, 2009, doi:10.1124/jpet.109.156448
    • Daniela Ponce-Balbuena,
    • Angélica López-Izquierdo,
    • Tania Ferrer,
    • Aldo A. Rodríguez-Menchaca,
    • Iván A. Aréchiga-Figueroa,
    • and José A. Sánchez-Chapula

    Tamoxifen Inhibits Inward Rectifier K+ 2.x Family of Inward Rectifier Channels by Interfering with Phosphatidylinositol 4,5-Bisphosphate-Channel Interactions

    J Pharmacol Exp Ther November 2009 331:563-573; published ahead of print August 4, 2009, doi:10.1124/jpet.109.156075
    • Kristina Hoffmann,
    • Younis Baqi,
    • María Sol Morena,
    • Markus Glänzel,
    • Christa E. Müller,
    • and Ivar von Kügelgen

    Interaction of New, Very Potent Non-Nucleotide Antagonists with Arg256 of the Human Platelet P2Y12 Receptor

    J Pharmacol Exp Ther November 2009 331:648-655; published ahead of print August 18, 2009, doi:10.1124/jpet.109.156687
    • Adam Sharp,
    • Simon J. Crabb,
    • Peter W. M. Johnson,
    • Angela Hague,
    • Ramsey Cutress,
    • Paul A. Townsend,
    • A. Ganesan,
    • and Graham Packham

    Thioflavin S (NSC71948) Interferes with Bcl-2-Associated Athanogene (BAG-1)-Mediated Protein-Protein Interactions

    J Pharmacol Exp Ther November 2009 331:680-689; published ahead of print August 18, 2009, doi:10.1124/jpet.109.153601
    • Richard A. Isbrucker,
    • Esther A. Guzmán,
    • Tara P. Pitts,
    • and Amy E. Wright

    Early Effects of Lasonolide A on Pancreatic Cancer Cells

    J Pharmacol Exp Ther November 2009 331:733-739; published ahead of print August 19, 2009, doi:10.1124/jpet.109.155531
    • Amadeu Gavaldà,
    • Montserrat Miralpeix,
    • Israel Ramos,
    • Raquel Otal,
    • Cristina Carreño,
    • Marisa Viñals,
    • Teresa Doménech,
    • Carla Carcasona,
    • Blanca Reyes,
    • Dolors Vilella,
    • Jordi Gras,
    • Julio Cortijo,
    • Esteban Morcillo,
    • Jesús Llenas,
    • Hamish Ryder,
    • and Jorge Beleta

    Characterization of Aclidinium Bromide, a Novel Inhaled Muscarinic Antagonist, with Long Duration of Action and a Favorable Pharmacological Profile

    J Pharmacol Exp Ther November 2009 331:740-751; published ahead of print August 26, 2009, doi:10.1124/jpet.109.151639

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Arthur Y. Shaw,
    • Meredith C. Henderson,
    • Gary Flynn,
    • Betty Samulitis,
    • Haiyong Han,
    • Steve P. Stratton,
    • H.-H. Sherry Chow,
    • Laurence H. Hurley,
    • and Robert T. Dorr

    Characterization of Novel Diaryl Oxazole-Based Compounds as Potential Agents to Treat Pancreatic Cancer

    J Pharmacol Exp Ther November 2009 331:636-647; published ahead of print August 5, 2009, doi:10.1124/jpet.109.156406

ENDOCRINE AND DIABETES

    • Sarah Melissa P. Jacobo,
    • Marcy L. Guerra,
    • and Gregory H. Hockerman

    Cav1.2 and Cav1.3 Are Differentially Coupled to Glucagon-Like Peptide-1 Potentiation of Glucose-Stimulated Insulin Secretion in the Pancreatic β-Cell Line INS-1

    J Pharmacol Exp Ther November 2009 331:724-732; published ahead of print August 26, 2009, doi:10.1124/jpet.109.158519

Cover image

Cover image expansion

About the cover: Homology model of the structure of the extracellular domain of the α3β4 nAChR derived from the structure of ACh binding proteins from Aplysia californica and Lymnaea stagnalis. See the article by Rana et al. on page 419 of this issue.

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This Issue

November 2009; 331 (2)
Cover
  1. HIGHLIGHTED PAPER
  2. PERSPECTIVES IN PHARMACOLOGY
  3. INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
  4. NEUROPHARMACOLOGY
  5. TOXICOLOGY
  6. CARDIOVASCULAR
  7. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
  8. BEHAVIORAL PHARMACOLOGY
  9. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  10. CELLULAR AND MOLECULAR
  11. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  12. ENDOCRINE AND DIABETES

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