Abstract
An instrument is described with which it is possible to differentiate the degrees of intoxication produced in rats by four doses of ethanol between 1.6 and 2.5 g/kg. The apparatus consists of a nylon belt moving continuously over an electrified grid. If the test animal fails to walk the belt in treadmill fashion, it is forced on to the grid, receiving a shock and activating a timer. The total time off the belt during the trial is linearly related to the blood ethanol level in the range of 150 to 300 mg/100 ml. Minimal training of the subject is required, and subsequent practice effect is negligible.
Footnotes
- Received May 15, 1967.
- Accepted August 22, 1967.
- © 1968 by The Williams & Wilkins Company
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