RT Journal Article
SR Electronic
T1 A TECHNIQUE FOR ACCURATE MEASUREMENT OF MODERATE DEGREES OF ALCOHOL INTOXICATION IN SMALL ANIMALS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 236
OP 242
VO 159
IS 1
A1 Gibbins, R. J.
A1 Kalant, H.
A1 Le Blanc, A. E.
YR 1968
UL http://jpet.aspetjournals.org/content/159/1/236.abstract
AB An instrument is described with which it is possible to differentiate the degrees of intoxication produced in rats by four doses of ethanol between 1.6 and 2.5 g/kg. The apparatus consists of a nylon belt moving continuously over an electrified grid. If the test animal fails to walk the belt in treadmill fashion, it is forced on to the grid, receiving a shock and activating a timer. The total time off the belt during the trial is linearly related to the blood ethanol level in the range of 150 to 300 mg/100 ml. Minimal training of the subject is required, and subsequent practice effect is negligible. © 1968 by The Williams & Wilkins Company