PT  - JOURNAL ARTICLE
AU  - Gibbins, R. J.
AU  - Kalant, H.
AU  - Le Blanc, A. E.
TI  - A TECHNIQUE FOR ACCURATE MEASUREMENT OF MODERATE DEGREES OF ALCOHOL INTOXICATION IN SMALL ANIMALS
DP  - 1968 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 236--242
VI  - 159
IP  - 1
4099  - http://jpet.aspetjournals.org/content/159/1/236.short
4100  - http://jpet.aspetjournals.org/content/159/1/236.full
SO  - J Pharmacol Exp Ther1968 Jan 01; 159
AB  - An instrument is described with which it is possible to differentiate the degrees of intoxication produced in rats by four doses of ethanol between 1.6 and 2.5 g/kg. The apparatus consists of a nylon belt moving continuously over an electrified grid. If the test animal fails to walk the belt in treadmill fashion, it is forced on to the grid, receiving a shock and activating a timer. The total time off the belt during the trial is linearly related to the blood ethanol level in the range of 150 to 300 mg/100 ml. Minimal training of the subject is required, and subsequent practice effect is negligible. © 1968 by The Williams & Wilkins Company