Abstract
Gamma-aminobutyric acid (GABA) has been shown to have weak depressant activity on synaptic transmission in the inferior mesenteric ganglion of the decerebrate cat.
High doses (100 µg/kg) administered intra arterially were necessary to elicit a depression.
The sensitivity of the preparations varied widely and tachyphylaxis was observed in some experiments.
No effect could be obtained in the superior cervical ganglion.
Footnotes
- Received September 17, 1960.
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