PT - JOURNAL ARTICLE AU - Richard J. Matthews AU - Barbara J. Roberts TI - THE EFFECT OF <em>GAMMA</em>-AMINOBUTYRIC ACID ON SYNAPTIC TRANSMISSION IN AUTONOMIC GANGLIA DP - 1961 Apr 01 TA - Journal of Pharmacology and Experimental Therapeutics PG - 19--22 VI - 132 IP - 1 4099 - http://jpet.aspetjournals.org/content/132/1/19.short 4100 - http://jpet.aspetjournals.org/content/132/1/19.full SO - J Pharmacol Exp Ther1961 Apr 01; 132 AB - Gamma-aminobutyric acid (GABA) has been shown to have weak depressant activity on synaptic transmission in the inferior mesenteric ganglion of the decerebrate cat. High doses (100 µg/kg) administered intra arterially were necessary to elicit a depression. The sensitivity of the preparations varied widely and tachyphylaxis was observed in some experiments. No effect could be obtained in the superior cervical ganglion.