TY - JOUR T1 - THE EFFECT OF <em>GAMMA</em>-AMINOBUTYRIC ACID ON SYNAPTIC TRANSMISSION IN AUTONOMIC GANGLIA JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 19 LP - 22 VL - 132 IS - 1 AU - Richard J. Matthews AU - Barbara J. Roberts Y1 - 1961/04/01 UR - http://jpet.aspetjournals.org/content/132/1/19.abstract N2 - Gamma-aminobutyric acid (GABA) has been shown to have weak depressant activity on synaptic transmission in the inferior mesenteric ganglion of the decerebrate cat. High doses (100 µg/kg) administered intra arterially were necessary to elicit a depression. The sensitivity of the preparations varied widely and tachyphylaxis was observed in some experiments. No effect could be obtained in the superior cervical ganglion. ER -