Abstract
Tetraethylammonium and mecamylamine potentiated the contractile responses of isolated arterial strips to all vasoexcitatory agents studied including epinephrine, norepinephrine, angiotonin, serotonin, histamine and barium chloride. These two agents also augmented the pressor response to epinephrine in cats after bilateral vagotomy and pithing of the spinal cord. Hexamethonium, chlorisondamine and pentolinium did not augment the contractile response of arterial strips or the pressor response of the vagotomized pithed cat to epinephrine.
It is concluded that potentiation of the pressor response to epinephrine and other drugs by TEA and mecamylamine in intact animals is due in part to a direct action of these agents on vascular effector cells, an action which is independent of ganglionic blockade. The mechanism of this potentiating action directly on vascular effector cells is discussed.
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