Abstract
In the rat surgical hepatectomy (evisceration) reduces the lethal dose and elimination of g-strophanthin. Exclusion of the kidney has no detectable effects on the lethal dose of this glycoside.
Carbon tetrachloride and phosphorus poisoning produces a reduction in the lethal dose of g-strophanthin. This reduction is due to the reduced excretion of g-strophanthin by the liver and to an increase in the sensitivity of the rat heart to g-strophanthin.
Footnotes
- Received January 31, 1949.
- 1949 by The American Society for Pharmacology and Experimental Therapeutics
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