PT  - JOURNAL ARTICLE
AU  - A. FARAH
AU  - E. SMUSKOWICZ
TI  - THE EFFECT OF LIVER DAMAGE ON THE ACTIVITY OF G-STROPHANTHIN IN THE RAT
DP  - 1949 Jun 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 139--144
VI  - 96
IP  - 2
4099  - http://jpet.aspetjournals.org/content/96/2/139.short
4100  - http://jpet.aspetjournals.org/content/96/2/139.full
SO  - J Pharmacol Exp Ther1949 Jun 01; 96
AB  - In the rat surgical hepatectomy (evisceration) reduces the lethal dose and elimination of g-strophanthin. Exclusion of the kidney has no detectable effects on the lethal dose of this glycoside. Carbon tetrachloride and phosphorus poisoning produces a reduction in the lethal dose of g-strophanthin. This reduction is due to the reduced excretion of g-strophanthin by the liver and to an increase in the sensitivity of the rat heart to g-strophanthin. 1949 by The American Society for Pharmacology and Experimental Therapeutics