RT Journal Article
SR Electronic
T1 THE EFFECT OF LIVER DAMAGE ON THE ACTIVITY OF G-STROPHANTHIN IN THE RAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 139
OP 144
VO 96
IS 2
A1 FARAH, A.
A1 SMUSKOWICZ, E.
YR 1949
UL http://jpet.aspetjournals.org/content/96/2/139.abstract
AB In the rat surgical hepatectomy (evisceration) reduces the lethal dose and elimination of g-strophanthin. Exclusion of the kidney has no detectable effects on the lethal dose of this glycoside. Carbon tetrachloride and phosphorus poisoning produces a reduction in the lethal dose of g-strophanthin. This reduction is due to the reduced excretion of g-strophanthin by the liver and to an increase in the sensitivity of the rat heart to g-strophanthin. 1949 by The American Society for Pharmacology and Experimental Therapeutics