Abstract
A variety of central depressant drugs, including sedatives, hypnotics, analgetics, fixed and volatile anesthetics, during the course of their pharmacological action result in a significant elevation of brain 5-hydroxytryptamine as determined by biological assay (V. mercenaria). Similar increases in brain 5-hydroxytryptamine have been detected by fluorimetry following treatment of rats with pentobarbital, chloral hydrate and diphenylhydantoin.
The possible role of these changes of brain 5-hydroxytryptamine in the production of the altered physiological state produced by the group of drugs in question is discussed.
Footnotes
- Received June 29, 1961.
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