PT  - JOURNAL ARTICLE
AU  - Bonnycastle, D. D.
AU  - Bonnycastle, M. F.
AU  - Anderson, E. G.
TI  - THE EFFECT OF A NUMBER OF CENTRAL DEPRESSANT DRUGS UPON BRAIN 5-HYDROXYTRYPTAMINE LEVELS IN THE RAT
DP  - 1962 Jan 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 17--20
VI  - 135
IP  - 1
4099  - http://jpet.aspetjournals.org/content/135/1/17.short
4100  - http://jpet.aspetjournals.org/content/135/1/17.full
SO  - J Pharmacol Exp Ther1962 Jan 01; 135
AB  - A variety of central depressant drugs, including sedatives, hypnotics, analgetics, fixed and volatile anesthetics, during the course of their pharmacological action result in a significant elevation of brain 5-hydroxytryptamine as determined by biological assay (V. mercenaria). Similar increases in brain 5-hydroxytryptamine have been detected by fluorimetry following treatment of rats with pentobarbital, chloral hydrate and diphenylhydantoin. The possible role of these changes of brain 5-hydroxytryptamine in the production of the altered physiological state produced by the group of drugs in question is discussed.