RT Journal Article
SR Electronic
T1 THE EFFECT OF A NUMBER OF CENTRAL DEPRESSANT DRUGS UPON BRAIN 5-HYDROXYTRYPTAMINE LEVELS IN THE RAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 17
OP 20
VO 135
IS 1
A1 Bonnycastle, D. D.
A1 Bonnycastle, M. F.
A1 Anderson, E. G.
YR 1962
UL http://jpet.aspetjournals.org/content/135/1/17.abstract
AB A variety of central depressant drugs, including sedatives, hypnotics, analgetics, fixed and volatile anesthetics, during the course of their pharmacological action result in a significant elevation of brain 5-hydroxytryptamine as determined by biological assay (V. mercenaria). Similar increases in brain 5-hydroxytryptamine have been detected by fluorimetry following treatment of rats with pentobarbital, chloral hydrate and diphenylhydantoin. The possible role of these changes of brain 5-hydroxytryptamine in the production of the altered physiological state produced by the group of drugs in question is discussed.