Abstract
Methaminodiazepoxide shows muscle relaxant and sedative effects in mice. It depresses avoidance responding and spontaneous locomotor activity of normal rats and has a calming effect on rats made irritable by lesions in the septal area of the brain.
In dogs, it produced ataxia at doses below those causing sleep. In monkeys, a loss of agressive behavior was observed at doses which did not depress general activity or avoidance behavior.
This compound showed anticonvulsant activity in mice and anti-inflammatory effects in rats. It produced appetite stimulation in rats and dogs.
Chronic administration to rats and dogs did not produce severe toxic manifestations; no evidence of cumulative toxicity or deleterious effects on the processes of reproduction were detected.
Footnotes
- Received October 15, 1959.
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