%0 Journal Article %A Lowell O. Randall %A William Schallek %A George A. Heise %A Eaden F. Keith %A Robert E. Bagdon %T THE PSYCHOSEDATIVE PROPERTIES OF METHAMINODIAZEPOXIDE %D 1960 %J Journal of Pharmacology and Experimental Therapeutics %P 163-171 %V 129 %N 2 %X Methaminodiazepoxide shows muscle relaxant and sedative effects in mice. It depresses avoidance responding and spontaneous locomotor activity of normal rats and has a calming effect on rats made irritable by lesions in the septal area of the brain. In dogs, it produced ataxia at doses below those causing sleep. In monkeys, a loss of agressive behavior was observed at doses which did not depress general activity or avoidance behavior. This compound showed anticonvulsant activity in mice and anti-inflammatory effects in rats. It produced appetite stimulation in rats and dogs. Chronic administration to rats and dogs did not produce severe toxic manifestations; no evidence of cumulative toxicity or deleterious effects on the processes of reproduction were detected. %U https://jpet.aspetjournals.org/content/jpet/129/2/163.full.pdf