RT Journal Article
SR Electronic
T1 THE PSYCHOSEDATIVE PROPERTIES OF METHAMINODIAZEPOXIDE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 163
OP 171
VO 129
IS 2
A1 Lowell O. Randall
A1 William Schallek
A1 George A. Heise
A1 Eaden F. Keith
A1 Robert E. Bagdon
YR 1960
UL http://jpet.aspetjournals.org/content/129/2/163.abstract
AB Methaminodiazepoxide shows muscle relaxant and sedative effects in mice. It depresses avoidance responding and spontaneous locomotor activity of normal rats and has a calming effect on rats made irritable by lesions in the septal area of the brain. In dogs, it produced ataxia at doses below those causing sleep. In monkeys, a loss of agressive behavior was observed at doses which did not depress general activity or avoidance behavior. This compound showed anticonvulsant activity in mice and anti-inflammatory effects in rats. It produced appetite stimulation in rats and dogs. Chronic administration to rats and dogs did not produce severe toxic manifestations; no evidence of cumulative toxicity or deleterious effects on the processes of reproduction were detected.