Abstract
1. In sufficient dose, morphinan, 6-methyldihydromorphine, and dihydrocodeinone induce morphine-like euphoria in former morphine addicts.
2. Dihydrocodeinone is very effective in relieving signs of abstinence from morphine.
3. 6-Methyldihydromorphine is relatively ineffective in abolishing the objective signs of abstinence from morphine but, in high doses, relieves the subjective complaints associated with withdrawal of morphine.
4. During experimental chronic administration of all three drugs to former morphine addicts, partial tolerance to the sedative action was observed and, in all three instances, morphine-like regressive behavior appeared.
5. Definite signs of abstinence were observed after withdrawal of all three drugs. These were most severe after withdrawal of morphinan, less severe following withdrawal of dihydrocodeinone, and were mild after withdrawal of 6-methyldihydromorphine.
6. Morphinan, 6-methylidihydromorphine and dihydrocodeinone all possess addiction liability.
Footnotes
- Received May 22, 1950.
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