RT Journal Article
SR Electronic
T1 ADDICTION LIABILITIES OF MORPHINAN, 6-METHYLDIHYDRO-MORPHINE AND DIHYDROCODEINONE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 128
OP 135
VO 100
IS 2
A1 Fraser, H. F.
A1 Isbell, Harris
YR 1950
UL http://jpet.aspetjournals.org/content/100/2/128.abstract
AB 1. In sufficient dose, morphinan, 6-methyldihydromorphine, and dihydrocodeinone induce morphine-like euphoria in former morphine addicts. 2. Dihydrocodeinone is very effective in relieving signs of abstinence from morphine. 3. 6-Methyldihydromorphine is relatively ineffective in abolishing the objective signs of abstinence from morphine but, in high doses, relieves the subjective complaints associated with withdrawal of morphine. 4. During experimental chronic administration of all three drugs to former morphine addicts, partial tolerance to the sedative action was observed and, in all three instances, morphine-like regressive behavior appeared. 5. Definite signs of abstinence were observed after withdrawal of all three drugs. These were most severe after withdrawal of morphinan, less severe following withdrawal of dihydrocodeinone, and were mild after withdrawal of 6-methyldihydromorphine. 6. Morphinan, 6-methylidihydromorphine and dihydrocodeinone all possess addiction liability.