Abstract
l-ABT is a hypotensive agent; d-ABT produces a biphasic blood pressure response—a rise is followed by a fall. The rise results from epinephrine release. The exact mechanism for the hypotensive actions following d- and l-ABT is unknown.
d- and l-ABT slow the heart slightly and decrease the amplitude of heart contractions.
Suppression of nictitating membrane contractions evoked by postganglionic stimulation was noted following d- and l-ABT. These substances also blocked hypertension caused by stimulation of the hepatic nerve.
d- and l-ABT potentiate muscle paralysis by d-tubocurarine.
APMT produces moderate rises in blood pressure and occasionally some enhancement of gut activity. The significance of this relative lack of pharmacological response is discussed.
Footnotes
- Received February 27, 1959.
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