RT Journal Article
SR Electronic
T1 THE PHARMACOLOGICAL EFFECTS OF D- AND L-2-AMINOBUTYLISOTHI-URONIUM BROMIDE HYDROBROMIDE AND 3-AMINOPROPYL-N'-METHYL ISOTHIURONIUM BROMIDE HYDROBROMIDE IN THE CAT
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 304
OP 311
VO 126
IS 4
A1 DiStefano, Victor
A1 Leary, Daniel E.
YR 1959
UL http://jpet.aspetjournals.org/content/126/4/304.abstract
AB l-ABT is a hypotensive agent; d-ABT produces a biphasic blood pressure response—a rise is followed by a fall. The rise results from epinephrine release. The exact mechanism for the hypotensive actions following d- and l-ABT is unknown. d- and l-ABT slow the heart slightly and decrease the amplitude of heart contractions. Suppression of nictitating membrane contractions evoked by postganglionic stimulation was noted following d- and l-ABT. These substances also blocked hypertension caused by stimulation of the hepatic nerve. d- and l-ABT potentiate muscle paralysis by d-tubocurarine. APMT produces moderate rises in blood pressure and occasionally some enhancement of gut activity. The significance of this relative lack of pharmacological response is discussed.