PT  - JOURNAL ARTICLE
AU  - Victor DiStefano
AU  - Daniel E. Leary
TI  - THE PHARMACOLOGICAL EFFECTS OF D- AND L-2-AMINOBUTYLISOTHI-URONIUM BROMIDE HYDROBROMIDE AND 3-AMINOPROPYL-N'-METHYL ISOTHIURONIUM BROMIDE HYDROBROMIDE IN THE CAT
DP  - 1959 Aug 01
TA  - Journal of Pharmacology and Experimental Therapeutics
PG  - 304--311
VI  - 126
IP  - 4
4099  - http://jpet.aspetjournals.org/content/126/4/304.short
4100  - http://jpet.aspetjournals.org/content/126/4/304.full
SO  - J Pharmacol Exp Ther1959 Aug 01; 126
AB  - l-ABT is a hypotensive agent; d-ABT produces a biphasic blood pressure response—a rise is followed by a fall. The rise results from epinephrine release. The exact mechanism for the hypotensive actions following d- and l-ABT is unknown. d- and l-ABT slow the heart slightly and decrease the amplitude of heart contractions. Suppression of nictitating membrane contractions evoked by postganglionic stimulation was noted following d- and l-ABT. These substances also blocked hypertension caused by stimulation of the hepatic nerve. d- and l-ABT potentiate muscle paralysis by d-tubocurarine. APMT produces moderate rises in blood pressure and occasionally some enhancement of gut activity. The significance of this relative lack of pharmacological response is discussed.