Journal of Pharmacology and Experimental Therapeutics: 371 (1)

October 01, 2019; Volume 371,Issue 1

Behavioral Pharmacology

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Repeated Intraperitoneal Administration of Low-Concentration Methylcellulose Leads to Systemic Histologic Lesions Without Loss of Preclinical Phenotype
Stacey Meeker, Megan Beckman, Kevin M. Knox, Piper M. Treuting and Melissa Barker-Haliski

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 25-35; DOI: https://doi.org/10.1124/jpet.119.257261

Cardiovascular

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Short Periods of Hypoxia Upregulate Sphingosine Kinase 1 and Increase Vasodilation of Arteries to Sphingosine 1-Phosphate (S1P) via S1P₃
H. Alganga, T.A.M. Almabrouk, O.J. Katwan, C.J. Daly, S. Pyne, N.J. Pyne and S. Kennedy

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 63-74; DOI: https://doi.org/10.1124/jpet.119.257931
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Triiodothyronine Reduces Vascular Dysfunction Associated with Hypertension by Attenuating Protein Kinase G/Vasodilator-Stimulated Phosphoprotein Signaling
Maria Alicia Carrillo-Sepulveda, Anjali Panackal, Renjith Maracheril, Nicole Maddie, Mitul N. Patel, Kaie Ojamaa, Olga V. Savinova and A. Martin Gerdes

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 88-94; DOI: https://doi.org/10.1124/jpet.119.260471

Drug Discovery and Translational Medicine

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Evaluation of Factor VIII Polysialylation: Identification of a Longer-Acting Experimental Therapy in Mice and Monkeys
Helmut Glantschnig, Alexander Bauer, Karima Benamara, Michael Dockal, Veronika Ehrlich, Herbert Gritsch, Gerald Höbarth, Frank M. Horling, Alexandra Kopic, Peter Leidenmühler, Birgit M. Reipert, Hanspeter Rottensteiner, Tanja Ruthsatz, Gerald Schrenk, Maria Schuster, Peter L. Turecek, Alfred Weber, Martin Wolfsegger, Friedrich Scheiflinger and Werner Höllriegl

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 95-105; DOI: https://doi.org/10.1124/jpet.119.260067
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Revisiting the Pharmacodynamic Uroselectivity of α₁-Adrenergic Receptor Antagonists
Bruna Maria Castro Salomão Quaresma, Amanda Reis Pimenta, Anne Caroline Santos da Silva, André Sampaio Pupo, Luiz Antonio S. Romeiro, Claudia Lucia Martins Silva and François Noël

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 106-112; DOI: https://doi.org/10.1124/jpet.119.260216
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Modest Blood-Brain Barrier Permeability of the Cyclodextrin Kleptose: Modification by Efflux and Luminal Surface Binding
W.A. Banks, Kory Engelke, Kim M. Hansen, Kristin M. Bullock and Pericles Calias

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 121-129; DOI: https://doi.org/10.1124/jpet.119.260497
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An Inhibitor of Fatty Acid Synthase Thioesterase Domain with Improved Cytotoxicity against Breast Cancer Cells and Stability in Plasma
Leslie E. Lupien, Evan M. Dunkley, Margaret J. Maloy, Ian B. Lehner, Maxwell G. Foisey, Maddison E. Ouellette, Lionel D. Lewis, Darcy Bates Pooler, William B. Kinlaw and Paul W. Baures

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 171-185; DOI: https://doi.org/10.1124/jpet.119.258947
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Effect of Melatonin and Its Analogs on Tear Secretion
Francisco Javier Navarro Gil, Fernando Huete-Toral, Almudena Crooke, Carmen Olalla Dominguez Godinez, Gonzalo Carracedo and Jesús Pintor

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 186-190; DOI: https://doi.org/10.1124/jpet.119.259192

Gastrointestinal, Hepatic, Pulmonary, and Renal

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PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy
Xiaoyan Zhou, Eric S. Muise, Robin Haimbach, Iyassu K. Sebhat, Yonghua Zhu, Franklin Liu, Sandra C. Souza, Yanqing Kan, Shirly Pinto, David E. Kelley and Maarten Hoek

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 45-55; DOI: https://doi.org/10.1124/jpet.119.258244

Inflammation, Immunopharmacology, and Asthma

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Δ⁹-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7–Stimulated Human Coculture
Michael D. Rizzo, Robert B. Crawford, Anthony Bach, Sera Sermet, Andrea Amalfitano and Norbert E. Kaminski

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 191-201; DOI: https://doi.org/10.1124/jpet.119.260661
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Inhibition of Interleukin-23–Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt
Stephen B. Gauld, Sebastien Jacquet, Donna Gauvin, Craig Wallace, Yibing Wang, Richard McCarthy, Christian Goess, Laura Leys, Susan Huang, Zhi Su, Rebecca Edelmayer, Joseph Wetter, Katherine Salte, Steven P. McGaraughty, Maria A. Argiriadi, Prisca Honore, Jean-Michel Luccarini, Didier Bressac, Kelly Desino, Eric Breinlinger, Kevin Cusack, Dominique Potin, Michael E. Kort and Philippe J Masson

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 208-218; DOI: https://doi.org/10.1124/jpet.119.258046

Metabolism, Transport, and Pharmacogenomics

Open Access
Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol
Rob C. Van Wijk, Elke H.J. Krekels, Vasudev Kantae, Anita Ordas, Thijs Kreling, Amy C. Harms, Thomas Hankemeier, Herman P. Spaink and Piet H. van der Graaf

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 15-24; DOI: https://doi.org/10.1124/jpet.119.260299
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In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues
Shiyan Chen, Karl Austin-Muttitt, Linghua Harris Zhang, Jonathan G. L. Mullins and Aik Jiang Lau

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 75-86; DOI: https://doi.org/10.1124/jpet.119.259267
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Effect of Pregnancy on Paroxetine-Induced Adiposity and Glucose Intolerance in Mice
Weibin Zha, Tao Hu, Mary F. Hebert and Joanne Wang

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 113-120; DOI: https://doi.org/10.1124/jpet.118.255380
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Simultaneous Assessment of Hepatic Transport and Metabolism Pathways with a Single Probe Using Individualized PBPK Modeling of ¹⁴CO₂ Production Rate Data
Yoko Franchetti and Thomas D. Nolin

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 151-161; DOI: https://doi.org/10.1124/jpet.119.257212
Open Access
Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor
Tetsuya Taniguchi, Naoki Ashizawa, Koji Matsumoto, Ryo Saito, Keisuke Motoki, Miku Sakai, Noriko Chikamatsu, Chiharu Hagihara, Masamichi Hashiba and Takashi Iwanaga

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 162-170; DOI: https://doi.org/10.1124/jpet.119.259341
Open Access
Absence of Pharmacokinetic Interactions between the Bruton’s Tyrosine Kinase Inhibitor Fenebrutinib and Methotrexate
Nicholas Steven Jones, Helen Winter, Tamiko R. Katsumoto, Marilyn Florero, Elaine Murray, Helen Walker, Nand Singh and Leslie W. Chinn

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 202-207; DOI: https://doi.org/10.1124/jpet.119.257089

Neuropharmacology

Open Access
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D₂ Receptor Mechanism of Action
Nina Dedic, Philip G. Jones, Seth C. Hopkins, Robert Lew, Liming Shao, John E. Campbell, Kerry L. Spear, Thomas H. Large, Una C. Campbell, Taleen Hanania, Emer Leahy and Kenneth S. Koblan

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 1-14; DOI: https://doi.org/10.1124/jpet.119.260281
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The Role of Biogenic Amine Transporters in Trace Amine–Associated Receptor 1 Regulation of Methamphetamine-Induced Neurotoxicity
Nicholas B. Miner, Tamara J. Phillips and Aaron Janowsky

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 36-44; DOI: https://doi.org/10.1124/jpet.119.258970
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Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171
Max V. McDermott, Leela Afrose, Ivone Gomes, Lakshmi A. Devi and Erin N. Bobeck

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 56-62; DOI: https://doi.org/10.1124/jpet.119.259242
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High Accumulation of Methadone Compared with Buprenorphine in Fetal Rat Brain after Maternal Exposure
Mette Kongstorp, Inger Lise Bogen, Tom Stiris and Jannike Mørch Andersen

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 130-137; DOI: https://doi.org/10.1124/jpet.119.259531
Open Access
Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice
Kufreobong E. Inyang, Michael D. Burton, Thomas Szabo-Pardi, Emma Wentworth, Timothy A. McDougal, Eric D. Ramirez, Grishma Pradhan, Gregory Dussor and Theodore J. Price

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 138-150; DOI: https://doi.org/10.1124/jpet.119.258400
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Tetrabenazine Facilitates Exocytosis by Enhancing Calcium-Induced Calcium Release through Ryanodine Receptors
Ricardo de Pascual, Nuria Álvarez-Ortego, Cristóbal de los Ríos, Gema Jacob-Mazariego and Antonio G. García

Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 219-230; DOI: https://doi.org/10.1124/jpet.119.256560

Erratum

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Correction to “Mechanistic Basis of Cabotegravir–Glucuronide Disposition in Humans”
Journal of Pharmacology and Experimental Therapeutics October 2019, 371 (1) 87; DOI: https://doi.org/10.1124/jpet.119.258384err

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Table of Contents

Behavioral Pharmacology

Cardiovascular

Drug Discovery and Translational Medicine

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Erratum

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