Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Kirk R Henne; Brandon Ason; Monique Howard; Wei Wang; Jeonghoon Sun; Jared Higbee; Jie Tang; Katherine C Matsuda; Ren Xu; Lei Zhou; Joyce C Y Chan; Chadwick King; Derek E Piper; Randal R Ketchem; Mark Leo Michaels; Simon M Jackson; Marc W Retter

doi:10.1124/jpet.114.221242

Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C Matsuda, Ren Xu, Lei Zhou, Joyce C Y Chan, Chadwick King, Derek E Piper, Randal R Ketchem, Mark Leo Michaels, Simon M Jackson and Marc W Retter

Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242

Kirk R Henne

Amgen, Inc.

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Brandon Ason

Amgen, Inc.

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Monique Howard

Amgen, Inc.

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Wei Wang

Amgen, Inc.

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Jeonghoon Sun

Amgen, Inc.

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Jared Higbee

Amgen, Inc.

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Jie Tang

Amgen, Inc.

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Katherine C Matsuda

Amgen, Inc.

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Ren Xu

Amgen, Inc.

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Lei Zhou

Amgen, Inc.

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Joyce C Y Chan

Amgen, Inc.

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Chadwick King

Amgen, Inc.

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Derek E Piper

Amgen, Inc.

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Randal R Ketchem

Amgen, Inc.

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Mark Leo Michaels

Amgen, Inc.

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Simon M Jackson

Amgen, Inc.

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Marc W Retter

Amgen, Inc.

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Journal of Pharmacology and Experimental Therapeutics

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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242

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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242

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Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

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Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

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