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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C Matsuda, Ren Xu, Lei Zhou, Joyce C Y Chan, Chadwick King, Derek E Piper, Randal R Ketchem, Mark Leo Michaels, Simon M Jackson and Marc W Retter
Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242

Article Information

jpet.114.221242
DOI 
https://doi.org/10.1124/jpet.114.221242
PubMed 
25653417
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online February 4, 2015.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kirk R Henne*,
  2. Brandon Ason,
  3. Monique Howard,
  4. Wei Wang,
  5. Jeonghoon Sun,
  6. Jared Higbee,
  7. Jie Tang,
  8. Katherine C Matsuda,
  9. Ren Xu,
  10. Lei Zhou,
  11. Joyce C Y Chan,
  12. Chadwick King,
  13. Derek E Piper,
  14. Randal R Ketchem,
  15. Mark Leo Michaels,
  16. Simon M Jackson, and
  17. Marc W Retter
  1. Amgen, Inc.
  1. ↵* Corresponding author; email: khenne{at}amgen.com

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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C Matsuda, Ren Xu, Lei Zhou, Joyce C Y Chan, Chadwick King, Derek E Piper, Randal R Ketchem, Mark Leo Michaels, Simon M Jackson and Marc W Retter
Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242
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