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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C Matsuda, Ren Xu, Lei Zhou, Joyce C Y Chan, Chadwick King, Derek E Piper, Randal R Ketchem, Mark Leo Michaels, Simon M Jackson and Marc W Retter
Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242
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Research ArticleDrug Discovery and Translational Medicine

Anti-PCSK9 Antibody Pharmacokinetics and LDL-C Pharmacodynamics in Non-Human Primates Are Antigen Affinity-Dependent and Exhibit Limited Sensitivity to FcRn Binding Enhancement

Kirk R Henne, Brandon Ason, Monique Howard, Wei Wang, Jeonghoon Sun, Jared Higbee, Jie Tang, Katherine C Matsuda, Ren Xu, Lei Zhou, Joyce C Y Chan, Chadwick King, Derek E Piper, Randal R Ketchem, Mark Leo Michaels, Simon M Jackson and Marc W Retter
Journal of Pharmacology and Experimental Therapeutics February 4, 2015, jpet.114.221242; DOI: https://doi.org/10.1124/jpet.114.221242
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