Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

Cassandra Koole; Denise Wootten; John Simms; Laurence J Miller; Arthur Christopoulos; Patrick M Sexton

doi:10.1124/jpet.114.220913

Research ArticleDrug Discovery and Translational Medicine

Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

Cassandra Koole, Denise Wootten, John Simms, Laurence J Miller, Arthur Christopoulos and Patrick M Sexton

Journal of Pharmacology and Experimental Therapeutics January 28, 2015, jpet.114.220913; DOI: https://doi.org/10.1124/jpet.114.220913

Cassandra Koole

1 Monash University;

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Denise Wootten

2 Moansh University;

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John Simms

3 Aston University;

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Laurence J Miller

4 Mayo Clinic

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Arthur Christopoulos

1 Monash University;

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Patrick M Sexton

1 Monash University;

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Journal of Pharmacology and Experimental Therapeutics

Vol. 391, Issue 3

1 Dec 2024

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Research ArticleDrug Discovery and Translational Medicine

Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

Cassandra Koole, Denise Wootten, John Simms, Laurence J Miller, Arthur Christopoulos and Patrick M Sexton

Journal of Pharmacology and Experimental Therapeutics January 28, 2015, jpet.114.220913; DOI: https://doi.org/10.1124/jpet.114.220913

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Research ArticleDrug Discovery and Translational Medicine

Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

Cassandra Koole, Denise Wootten, John Simms, Laurence J Miller, Arthur Christopoulos and Patrick M Sexton

Journal of Pharmacology and Experimental Therapeutics January 28, 2015, jpet.114.220913; DOI: https://doi.org/10.1124/jpet.114.220913

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Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

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Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

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