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Research ArticleDrug Discovery and Translational Medicine

Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

Cassandra Koole, Denise Wootten, John Simms, Laurence J Miller, Arthur Christopoulos and Patrick M Sexton
Journal of Pharmacology and Experimental Therapeutics January 28, 2015, jpet.114.220913; DOI: https://doi.org/10.1124/jpet.114.220913

Article Information

jpet.114.220913
DOI 
https://doi.org/10.1124/jpet.114.220913
PubMed 
25630467
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0022-3565
Online ISSN 
1521-0103
History 
  • Published online January 28, 2015.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Cassandra Koole1,
  2. Denise Wootten2,
  3. John Simms3,
  4. Laurence J Miller4,
  5. Arthur Christopoulos1, and
  6. Patrick M Sexton1,*
  1. 1 Monash University;
  2. 2 Moansh University;
  3. 3 Aston University;
  4. 4 Mayo Clinic
  1. ↵* Corresponding author; email: patrick.sexton{at}monash.edu

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Research ArticleDrug Discovery and Translational Medicine

Differential Impact of Amino Acid Substitutions on Critical Residues of the Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Involved in Peptide Activity and Small Molecule Allostery

Cassandra Koole, Denise Wootten, John Simms, Laurence J Miller, Arthur Christopoulos and Patrick M Sexton
Journal of Pharmacology and Experimental Therapeutics January 28, 2015, jpet.114.220913; DOI: https://doi.org/10.1124/jpet.114.220913
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