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A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor
Alastair G. Kerr, Lawrence C. S. Tam, Ashley B. Hale, Milena Cioroch, Gillian Douglas, Sarina Agkatsev, Olivia Hibbitt, Joseph Mason, James Holt-Martyn, Carole J. R. Bataille, Graham M. Wynne, Keith M. Channon, Angela J. Russell and Richard Wade-Martins

Journal of Pharmacology and Experimental Therapeutics June 2017, 361 (3) 417-428; DOI: https://doi.org/10.1124/jpet.116.239574
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Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis
Carlos Antonio Trindade-da-Silva, Ahmed Bettaieb, Marcelo Henrique Napimoga, Kin Sing Stephen Lee, Bora Inceoglu, Carlos Ueira-Vieira, Donald Bruun, Sumanta Kumar Goswami, Fawaz G. Haj and Bruce D. Hammock

Journal of Pharmacology and Experimental Therapeutics June 2017, 361 (3) 408-416; DOI: https://doi.org/10.1124/jpet.116.238113
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Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell–Derived Neurons
Stefanie Traub, Heiko Stahl, Holger Rosenbrock, Eric Simon, Lore Florin, Lisa Hospach, Stefan Hörer and Ralf Heilker

Journal of Pharmacology and Experimental Therapeutics June 2017, 361 (3) 355-365; DOI: https://doi.org/10.1124/jpet.117.240184
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Dual Inhibition of Bruton’s Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin’s B Cell Malignancies
Jennifer Alfaro, Felipe Pérez de Arce, Sebastián Belmar, Glenda Fuentealba, Patricio Avila, Gonzalo Ureta, Camila Flores, Claudia Acuña, Luz Delgado, Diana Gaete, Brahmam Pujala, Anup Barde, Anjan K. Nayak, T. V. R. Upendra, Dhananjay Patel, Shailender Chauhan, Vijay K. Sharma, Stacy Kanno, Ramona G. Almirez, David T. Hung, Sarvajit Chakravarty, Roopa Rai, Sebastián Bernales, Kevin P. Quinn, Son M. Pham and Emma McCullagh

Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 312-321; DOI: https://doi.org/10.1124/jpet.116.238022
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Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy
Christopher T. Salatto, Russell A. Miller, Kimberly O. Cameron, Emily Cokorinos, Allan Reyes, Jessica Ward, Matthew F. Calabrese, Ravi G. Kurumbail, Francis Rajamohan, Amit S. Kalgutkar, David A. Tess, Andre Shavnya, Nathan E. Genung, David J. Edmonds, Aditi Jatkar, Benjamin S Maciejewski, Marina Amaro, Harmeet Gandhok, Mara Monetti, Katherine Cialdea, Eliza Bollinger, John M. Kreeger, Timothy M. Coskran, Alan C. Opsahl, Germaine G. Boucher, Morris J. Birnbaum, Paul DaSilva-Jardine and Tim Rolph

Journal of Pharmacology and Experimental Therapeutics May 2017, 361 (2) 303-311; DOI: https://doi.org/10.1124/jpet.116.237925
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Antibody-Conjugated, DNA-Based Nanocarriers Intercalated with Doxorubicin Eliminate Myofibroblasts in Explants of Human Lens Tissue
Jacquelyn Gerhart, Marvin Greenbaum, Lou Casta, Anthony Clemente, Keith Mathers, Robert Getts and Mindy George-Weinstein

Journal of Pharmacology and Experimental Therapeutics April 2017, 361 (1) 60-67; DOI: https://doi.org/10.1124/jpet.116.239079
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A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity
Christof T. Kaltenmeier, Laura L. Vollmer, Lawrence A. Vernetti, Lindsay Caprio, Keanu Davis, Vasiliy N. Korotchenko, Billy W. Day, Michael Tsang, Keren I. Hulkower, Michael T. Lotze and Andreas Vogt

Journal of Pharmacology and Experimental Therapeutics April 2017, 361 (1) 39-50; DOI: https://doi.org/10.1124/jpet.116.239756
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Characterizing Gemcitabine Effects Administered as Single Agent or Combined with Carboplatin in Mice Pancreatic and Ovarian Cancer Xenografts: A Semimechanistic Pharmacokinetic/Pharmacodynamics Tumor Growth-Response Model
Maria Garcia-Cremades, Celine Pitou, Philip W. Iversen and Iñaki F. Troconiz

Journal of Pharmacology and Experimental Therapeutics March 2017, 360 (3) 445-456; DOI: https://doi.org/10.1124/jpet.116.237610
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Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder
J. Di Salvo, H. Nagabukuro, L. A. Wickham, C. Abbadie, J. A. DeMartino, A. Fitzmaurice, L. Gichuru, A. Kulick, M. J. Donnelly, N. Jochnowitz, A. L. Hurley, A. Pereira, A. Sanfiz, G. Veronin, K. Villa, J. Woods, B. Zamlynny, E. Zycband, G.M. Salituro, T. Frenkl, A. E. Weber, S. D. Edmondson and M. Struthers

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 346-355; DOI: https://doi.org/10.1124/jpet.116.237313
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Reveglucosidase alfa (BMN 701), an IGF2-Tagged rhAcid α-Glucosidase, Improves Respiratory Functional Parameters in a Murine Model of Pompe Disease
Jeffrey Peng, Jill Dalton, Mark Butt, Kristin Tracy, Derek Kennedy, Peter Haroldsen, Rhea Cahayag, Stephen Zoog, Charles A. O’Neill and Laurie S. Tsuruda

Journal of Pharmacology and Experimental Therapeutics February 2017, 360 (2) 313-323; DOI: https://doi.org/10.1124/jpet.116.235952

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