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Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Jeremy H. Toyn, Kenneth M. Boy, Joseph Raybon, Jere E. Meredith, Alan S. Robertson, Valerie Guss, Nina Hoque, Francis Sweeney, Xiaoliang Zhuo, Wendy Clarke, Kimberly Snow, R. Rex Denton, Dmitry Zuev, Lorin A. Thompson, John Morrison, James Grace, Flora Berisha, Michael Furlong, Jun-Sheng Wang, Kimberly A. Lentz, Ramesh Padmanabha, Lynda Cook, Cong Wei, Dieter M. Drexler, John E. Macor, Charlie F. Albright, Maciej Gasior, Richard E. Olson, Quan Hong, Holly D. Soares, Malaz AbuTarif and Michael K. Ahlijanian

Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 125-137; DOI: https://doi.org/10.1124/jpet.116.232249
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Preferential Delivery of an Opioid Antagonist to the Fetal Brain in Pregnant Mice
John Oberdick, Yonghua Ling, Mitch A. Phelps, Max S. Yudovich, Karl Schilling and Wolfgang Sadee

Journal of Pharmacology and Experimental Therapeutics July 2016, 358 (1) 22-30; DOI: https://doi.org/10.1124/jpet.115.231902
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BI 1002494, a Novel Potent and Selective Oral Spleen Tyrosine Kinase Inhibitor, Displays Differential Potency in Human Basophils and B Cells
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Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 554-561; DOI: https://doi.org/10.1124/jpet.116.233155
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β-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1– and Oxidative Stress–Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis
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Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 466-475; DOI: https://doi.org/10.1124/jpet.116.232694
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TASP0434299: A Novel Pyridopyrimidin-4-One Derivative as a Radioligand for Vasopressin V_1B Receptor
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Journal of Pharmacology and Experimental Therapeutics June 2016, 357 (3) 495-508; DOI: https://doi.org/10.1124/jpet.116.232942
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Enolate-Forming Phloretin Pharmacophores: Hepatoprotection in an Experimental Model of Drug-Induced Toxicity
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Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies
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Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein–Coupled Receptor 84
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Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 337-344; DOI: https://doi.org/10.1124/jpet.116.232033
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Comparative Characterization of Hepatic Distribution and mRNA Reduction of Antisense Oligonucleotides Conjugated with Triantennary N-Acetyl Galactosamine and Lipophilic Ligands Targeting Apolipoprotein B
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Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 320-330; DOI: https://doi.org/10.1124/jpet.115.230300
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Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse
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Journal of Pharmacology and Experimental Therapeutics May 2016, 357 (2) 248-257; DOI: https://doi.org/10.1124/jpet.115.229542

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