Abstract

1) In isolated, blood-perfused dog lungs, with either negative or positive pressure ventilation, N-isopropyl-norepinephrine causes pulmonary vasodilatation. Such responses are obtained when the drug is administered by intravascular injection or by inhalation of a spray.

2) Cocaine, atropine, pilocarpine or ergotoxine (and related compounds) do not alter the direction of the response.

3) Under all of the conditions of experimentation employed here, N-isopropyl-norepinephrine has a strong bronchodilator action, its activity usually being ten times greater than that of epinephrine.