TY - JOUR T1 - VASO- AND BRONCHODILATOR EFFECTS OF N-ISOPROPYL-NOREPINEPHRINE IN ISOLATED PERFUSED DOG LUNGS JF - Journal of Pharmacology and Experimental Therapeutics JO - J Pharmacol Exp Ther SP - 228 LP - 237 VL - 96 IS - 3 AU - C. O. Hebb AU - H. Konzett Y1 - 1949/07/01 UR - http://jpet.aspetjournals.org/content/96/3/228.abstract N2 - 1) In isolated, blood-perfused dog lungs, with either negative or positive pressure ventilation, N-isopropyl-norepinephrine causes pulmonary vasodilatation. Such responses are obtained when the drug is administered by intravascular injection or by inhalation of a spray. 2) Cocaine, atropine, pilocarpine or ergotoxine (and related compounds) do not alter the direction of the response. 3) Under all of the conditions of experimentation employed here, N-isopropyl-norepinephrine has a strong bronchodilator action, its activity usually being ten times greater than that of epinephrine. ER -