Abstract
Morphine, codeine, meperidine, and methadon inhibit the oxidation of succinate by brain homogenate. Spectrographic data showed these drugs prevent the reduction of cytochrome c by the enzyme preparation and succinate indicating the block occurred at the dehydrogenase or an unknown factor. The inhibition of the oxidation of p-phenylenediamine by methadon shows blockage also occurs at the cytochrome-cytochrome oxidase level.
Footnotes
- Received October 13, 1948.
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