Abstract
1. No permanent ocular lesions were found in rabbits when an almost lethal dose or repeated small doses were applied to the eyes.
2. Local application to rabbits' eyes of di-isopropyl fluorophosphate vapor or solution causes intense miosis, lacrimation, transient increase in intraocular pressure.
3. 1.4 mgm./kg. applied to a rabbit's eye is lethal.
4. Atropine applied before di-isopropyl fluorophosphate prevents the development of the miosis; applied after the drug, it relaxes pupilary contraction.
Footnotes
- Received May 11, 1946.
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