RT Journal Article
SR Electronic
T1 STUDIES ON THE OCULAR REACTIONS OF RABBITS TO DI-ISOPROPYL FLUOROPHOSPHATE
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 23
OP 26
VO 88
IS 1
A1 SCHOLZ, ROY O.
YR 1946
UL http://jpet.aspetjournals.org/content/88/1/23.abstract
AB 1. No permanent ocular lesions were found in rabbits when an almost lethal dose or repeated small doses were applied to the eyes. 2. Local application to rabbits' eyes of di-isopropyl fluorophosphate vapor or solution causes intense miosis, lacrimation, transient increase in intraocular pressure. 3. 1.4 mgm./kg. applied to a rabbit's eye is lethal. 4. Atropine applied before di-isopropyl fluorophosphate prevents the development of the miosis; applied after the drug, it relaxes pupilary contraction.