Abstract
17 steroid compounds have been studied for luteoid activity. In agreement with some of the already known pharmaco-chemical correlations, it is concluded that the addition of a methyl, ethyl or ethynyl group at C17 markedly increases the progestational effect of parent compounds which possess only a slight degree of luteoid activity. This general rule has now been demonstrated for testosterone, dihydro-testosterone, Δ5-ANDROSTENE-3(β),17(α)-diol and ANDROSTANE-3(β),17(α-diol.
Comparative studies concerning three of the main pharmacologic activities of ethynyl-androstenediol and ethynyl-testosterone are reported. These indicate that ethynyl-androstenediol is only slightly less luteoid than ethynyl-testosterone, but considerably less testoid and more folliculoid than the latter compound. The practical significance of these observations is discussed.
Footnotes
- Received February 10, 1945.
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