RT Journal Article
SR Electronic
T1 ADDITIONAL STEROIDS WITH LUTEOID ACTIVITY
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 46
OP 52
VO 84
IS 1
A1 MASSON, GEORGES
A1 SELYE, HANS
YR 1945
UL http://jpet.aspetjournals.org/content/84/1/46.abstract
AB 17 steroid compounds have been studied for luteoid activity. In agreement with some of the already known pharmaco-chemical correlations, it is concluded that the addition of a methyl, ethyl or ethynyl group at C17 markedly increases the progestational effect of parent compounds which possess only a slight degree of luteoid activity. This general rule has now been demonstrated for testosterone, dihydro-testosterone, Δ5-ANDROSTENE-3(β),17(α)-diol and ANDROSTANE-3(β),17(α-diol. Comparative studies concerning three of the main pharmacologic activities of ethynyl-androstenediol and ethynyl-testosterone are reported. These indicate that ethynyl-androstenediol is only slightly less luteoid than ethynyl-testosterone, but considerably less testoid and more folliculoid than the latter compound. The practical significance of these observations is discussed.