Research ArticleNeuropharmacology
Open Access
Development of a Semimechanistic Pharmacokinetic-Pharmacodynamic Model Describing Dextroamphetamine Exposure and Striatal Dopamine Response in Rats and Nonhuman Primates following a Single Dose of Dextroamphetamine
Marcel M. van Gaalen, Christina Schlumbohm, Joost H. Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach and Robert E. Stratford Jr.
Journal of Pharmacology and Experimental Therapeutics April 2019, 369 (1) 107-120; DOI: https://doi.org/10.1124/jpet.118.254508
Marcel M. van Gaalen
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Christina Schlumbohm
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Joost H. Folgering
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Saugat Adhikari
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Chandrali Bhattacharya
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Douglas Steinbach
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Robert E. Stratford Jr.
Charles River Laboratories Germany GmbH, Göttingen, Germany (M.M.v.G., C.S.); Charles River Laboratories Den Bosch BV, 's-Hertogenbosch, The Netherlands (J.F.); Duquesne School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, Pennsylvania (S.A., C.B., D.S., R.E.S.)
Submit a Response to This Article
Jump to comment:
No eLetters have been published for this article.
In this issue
Research ArticleNeuropharmacology
d-Amphetamine Exposure/Dopamine Response in Rats and NHPs
Marcel M. van Gaalen, Christina Schlumbohm, Joost H. Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach and Robert E. Stratford
Journal of Pharmacology and Experimental Therapeutics April 1, 2019, 369 (1) 107-120; DOI: https://doi.org/10.1124/jpet.118.254508
Research ArticleNeuropharmacology
d-Amphetamine Exposure/Dopamine Response in Rats and NHPs
Marcel M. van Gaalen, Christina Schlumbohm, Joost H. Folgering, Saugat Adhikari, Chandrali Bhattacharya, Douglas Steinbach and Robert E. Stratford
Journal of Pharmacology and Experimental Therapeutics April 1, 2019, 369 (1) 107-120; DOI: https://doi.org/10.1124/jpet.118.254508
Jump to section
Related Articles
Cited By...
More in this TOC Section
Similar Articles
Advertisement