Journal of Pharmacology and Experimental Therapeutics: 351 (1)

October 01, 2014; Volume 351,Issue 1

Highlighted Papers

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Effect of α7 Nicotinic Receptor Agonist on L-Dopa–Induced Dyskinesias
Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 1; DOI: https://doi.org/10.1124/jpet.114.1014HI
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Pegylation Prevents Phospho-Ibuprofen Hydrolysis
Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 1; DOI: https://doi.org/10.1124/jpet.114.1014HIa
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Therapeutic Targeting of Src Kinase in Pulmonary Fibrosis
Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 1; DOI: https://doi.org/10.1124/jpet.114.1014HIb
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Pharmacology of GSK-961081, an Inhaled Muscarinic Antagonist/β₂ Agonist
Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 1; DOI: https://doi.org/10.1124/jpet.114.1014HIc

Commentary

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Common Misconceptions about Data Analysis and Statistics
Harvey J. Motulsky

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 200-205; DOI: https://doi.org/10.1124/jpet.114.219170

Minireviews

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The Neurokinin-1 Receptor in Addictive Processes
Jesse R. Schank

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 2-8; DOI: https://doi.org/10.1124/jpet.113.210799
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Dopamine D₁ Receptor Signaling: Does Gα_Q–Phospholipase C Actually Play a Role?
Sang-Min Lee, Yang Yang and Richard B. Mailman

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 9-17; DOI: https://doi.org/10.1124/jpet.114.214411
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Pharmacological Modulation of Caspase-8 in Thymus-Related Medical Conditions
Nicola Pozzesi, Alessandra Fierabracci, Trinh Thy Thuy, Maria Paola Martelli, Anna Marina Liberati, Emira Ayroldi, Carlo Riccardi and Domenico V. Delfino

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 18-24; DOI: https://doi.org/10.1124/jpet.114.216572

Behavioral Pharmacology

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The α7 Nicotinic Receptor Agonist ABT-107 Decreases l-Dopa–Induced Dyskinesias in Parkinsonian Monkeys
Danhui Zhang, Matthew McGregor, Michael W. Decker and Maryka Quik

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 25-32; DOI: https://doi.org/10.1124/jpet.114.216283
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Relationship between Cerebral Sigma-1 Receptor Occupancy and Attenuation of Cocaine’s Motor Stimulatory Effects in Mice by PD144418
John R. Lever, Dennis K. Miller, Emily A. Fergason-Cantrell, Caroline L. Green, Lisa D. Watkinson, Terry L. Carmack and Susan Z. Lever

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 153-163; DOI: https://doi.org/10.1124/jpet.114.216671
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Treatment with a Heme Oxygenase 1 Inducer Enhances the Antinociceptive Effects of µ-Opioid, δ-Opioid, and Cannabinoid 2 Receptors during Inflammatory Pain
Mireia Carcolé, Sílvia Castany, Sergi Leánez and Olga Pol

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 224-232; DOI: https://doi.org/10.1124/jpet.114.215681

Cardiovascular

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Racial Differences in Resistance to P2Y₁₂ Receptor Antagonists in Type 2 Diabetic Subjects
John H. Cleator, Matthew T. Duvernay, Michael Holinstat, Nancy E. Colowick, Willie J. Hudson, Yanna Song, Frank E. Harrell and Heidi E. Hamm

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 33-43; DOI: https://doi.org/10.1124/jpet.114.215616
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Neuronal Nitric Oxide Synthase–Dependent Elevation in Adiponectin in the Rostral Ventrolateral Medulla Underlies G Protein–Coupled Receptor 18–Mediated Hypotension in Conscious Rats
Anusha Penumarti and Abdel A. Abdel-Rahman

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 44-53; DOI: https://doi.org/10.1124/jpet.114.216036
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Modulation of Resistance Artery Tone by the Trace Amine β-Phenylethylamine: Dual Indirect Sympathomimetic and α₁-Adrenoceptor Blocking Actions
Deepak Narang, Paul M. Kerr, Stephanie E. Lunn, Rhys Beaudry, Julie Sigurdson, Margaret D. Lalies, Alan L. Hudson, Peter E. Light, Andrew Holt and Frances Plane

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 164-171; DOI: https://doi.org/10.1124/jpet.114.216523

Cellular and Molecular

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Resolvin D2 Supports MCF-7 Cell Proliferation via Activation of Estrogen Receptor
Nuha Al-Zaubai, Cameron N. Johnstone, May May Leong, John Li, Mark Rizzacasa and Alastair G. Stewart

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 172-180; DOI: https://doi.org/10.1124/jpet.114.214403

Chemotherapy, Antibiotics, and Gene Therapy

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Development of an Anti–Claudin-3 and -4 Bispecific Monoclonal Antibody for Cancer Diagnosis and Therapy
Xiangru Li, Manami Iida, Minoru Tada, Akihiro Watari, Yumi Kawahigashi, Yuka Kimura, Taku Yamashita, Akiko Ishii-Watabe, Tadayuki Uno, Masayoshi Fukasawa, Hiroki Kuniyasu, Kiyohito Yagi and Masuo Kondoh

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 206-213; DOI: https://doi.org/10.1124/jpet.114.216911

Drug Discovery and Translational Medicine

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Intranasal Administration as a Route for Drug Delivery to the Brain: Evidence for a Unique Pathway for Albumin
Joseph A. Falcone, Therese S. Salameh, Xiang Yi, Benjamin J. Cordy, William G. Mortell, Alexander V. Kabanov and William A. Banks

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 54-60; DOI: https://doi.org/10.1124/jpet.114.216705
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Pegylation Improves the Pharmacokinetics and Bioavailability of Small-Molecule Drugs Hydrolyzable by Esterases: A Study of Phospho-Ibuprofen
George Mattheolabakis, Chi C. Wong, Yu Sun, Carol A. Amella, Robert Richards, Panayiotis P. Constantinides and Basil Rigas

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 61-66; DOI: https://doi.org/10.1124/jpet.114.217208
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Translational Pharmacokinetic-Pharmacodynamic Modeling for an Orally Available Novel Inhibitor of Anaplastic Lymphoma Kinase and c-Ros Oncogene 1
Shinji Yamazaki, Justine L. Lam, Helen Y. Zou, Hui Wang, Tod Smeal and Paolo Vicini

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 67-76; DOI: https://doi.org/10.1124/jpet.114.217141

Endocrine and Diabetes

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Two Types of Overcontraction Are Involved in Intrarenal Artery Dysfunction in Type II Diabetic Mouse
Koji Nobe, Yasuhiro Takenouchi, Keizo Kasono, Terumasa Hashimoto and Kazuo Honda

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 77-86; DOI: https://doi.org/10.1124/jpet.114.216747
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HIS-388, a Novel Orally Active and Long-Acting 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, Ameliorates Insulin Sensitivity and Glucose Intolerance in Diet-Induced Obesity and Nongenetic Type 2 Diabetic Murine Models
Seiji Okazaki, Takehiro Takahashi, Tomokatsu Iwamura, Junko Nakaki, Yumiko Sekiya, Mai Yagi, Hiroki Kumagai, Mikiya Sato, Satoshi Sakami, Aiko Nitta, Koji Kawai and Mie Kainoh

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 181-189; DOI: https://doi.org/10.1124/jpet.114.216556

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Therapeutic Targeting of Src Kinase in Myofibroblast Differentiation and Pulmonary Fibrosis
Meng Hu, Pulin Che, Xiaosi Han, Guo-Qiang Cai, Gang Liu, Veena Antony, Tracy Luckhardt, Gene P. Siegal, Yong Zhou, Rui-ming Liu, Leena P. Desai, Philip J. O’Reilly, Victor J. Thannickal and Qiang Ding

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 87-95; DOI: https://doi.org/10.1124/jpet.114.216044
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Pharmacologic Characterization of GSK-961081 (TD-5959), a First-in-Class Inhaled Bifunctional Bronchodilator Possessing Muscarinic Receptor Antagonist and β₂-Adrenoceptor Agonist Properties
Sharath S. Hegde, Adam D. Hughes, Yan Chen, Tod Steinfeld, Jeffrey R. Jasper, Tae-Weon Lee, Alexander McNamara, William J. Martin, M. Teresa Pulido-Rios and Mathai Mammen

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 190-199; DOI: https://doi.org/10.1124/jpet.114.216861

Inflammation, Immunopharmacology, and Asthma

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Annexin A1 Mediates Hydrogen Sulfide Properties in the Control of Inflammation
Vincenzo Brancaleone, Emma Mitidieri, Roderick J. Flower, Giuseppe Cirino and Mauro Perretti

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 96-104; DOI: https://doi.org/10.1124/jpet.114.217034

Metabolism, Transport, and Pharmacogenomics

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Decreased Bile-Acid Synthesis in Livers of Hepatocyte-Conditional NADPH–Cytochrome P450 Reductase–Null Mice Results in Increased Bile Acids in Serum
Xingguo Cheng, Youcai Zhang and Curtis D. Klaassen

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 105-113; DOI: https://doi.org/10.1124/jpet.114.216796
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The Molecular Mechanism of Intestinal Levodopa Absorption and Its Possible Implications for the Treatment of Parkinson’s Disease
Simone M. R. Camargo, Raphael N. Vuille-dit-Bille, Luca Mariotta, Tamara Ramadan, Katja Huggel, Dustin Singer, Oliver Götze and François Verrey

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 114-123; DOI: https://doi.org/10.1124/jpet.114.216317
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Quantitative Prediction of Transporter- and Enzyme-Mediated Clinical Drug-Drug Interactions of Organic Anion-Transporting Polypeptide 1B1 Substrates Using a Mechanistic Net-Effect Model
Manthena V. Varma, Yi-an Bi, Emi Kimoto and Jian Lin

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 214-223; DOI: https://doi.org/10.1124/jpet.114.215970

Neuropharmacology

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Perampanel, an Antagonist of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors, for the Treatment of Epilepsy: Studies in Human Epileptic Brain and Nonepileptic Brain and in Rodent Models
R. Zwart, E. Sher, X. Ping, X. Jin, J. R. Sims, A. S. Chappell, S. D. Gleason, P. J. Hahn, K. Gardinier, D. L. Gernert, J. Hobbs, J. L. Smith, S. N. Valli and J. M. Witkin

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 124-133; DOI: https://doi.org/10.1124/jpet.114.212779
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Cyclooxygenase 2 Inhibitor Celecoxib Inhibits Glutamate Release by Attenuating the PGE₂/EP2 Pathway in Rat Cerebral Cortex Endings
Tzu-Yu Lin, Cheng-Wei Lu, Chia-Chuan Wang, Shu Kuei Huang and Su-Jane Wang

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 134-145; DOI: https://doi.org/10.1124/jpet.114.217372
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Synergistic Effect of 5-Hydroxytryptamine 3 and Neurokinin 1 Receptor Antagonism in Rodent Models of Somatic and Visceral Pain
Beverley Greenwood-Van Meerveld, Ehsan Mohammadi, Karl Tyler, Claudio Pietra, Lucy A. Bee and Anthony Dickenson

Journal of Pharmacology and Experimental Therapeutics October 2014, 351 (1) 146-152; DOI: https://doi.org/10.1124/jpet.114.216028

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Table of Contents

Highlighted Papers

Commentary

Minireviews

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

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