Journal of Pharmacology and Experimental Therapeutics: 350 (3)

September 01, 2014; Volume 350,Issue 3

Highlighted Papers

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Small-Molecule Correctors To Restore F508del-CFTR Function and Processing
Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HI
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Tanshinone II A Sulfonate Inhibits P2X7
Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HIa
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Empagliflozin Preserves β-Cell Mass and Restores Glucose Homeostasis in Diabetes
Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HIb
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Gambierol Augments Spontaneous Ca²⁺ Oscillations in Cerebrocortical Neurons
Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 479; DOI: https://doi.org/10.1124/jpet.114.0914HIc

Commentary

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Hope for Disease-Modifying Treatment of Systemic Sclerosis/Scleroderma
Martin C. Michel

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 480-482; DOI: https://doi.org/10.1124/jpet.114.213520comm

Minireview

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Translating Curcumin to the Clinic for Lung Cancer Prevention: Evaluation of the Preclinical Evidence for Its Utility in Primary, Secondary, and Tertiary Prevention Strategies
Lynne M. Howells, Jagdish Mahale, Stewart Sale, Laura McVeigh, William P. Steward, Anne Thomas and Karen Brown

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 483-494; DOI: https://doi.org/10.1124/jpet.114.216333

Cardiovascular

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Different Compartmentation of Responses to Brain Natriuretic Peptide and C-Type Natriuretic Peptide in Failing Rat Ventricle
Lise Román Moltzau, Jan Magnus Aronsen, Silja Meier, Jonas Skogestad, Øivind Ørstavik, Gustav B. Lothe, Ivar Sjaastad, Tor Skomedal, Jan-Bjørn Osnes, Finn Olav Levy and Eirik Qvigstad

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 681-690; DOI: https://doi.org/10.1124/jpet.114.214882
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Uptake and Protective Effects of Ergothioneine in Human Endothelial Cells
Rachel W. S. Li, C. Yang, Albert S. M. Sit, Y. W. Kwan, Simon M. Y. Lee, Maggie P. M. Hoi, S. W. Chan, Marvin Hausman, Paul M. Vanhoutte and George P. H. Leung

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 691-700; DOI: https://doi.org/10.1124/jpet.114.214049
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Targeted Injection of a Biocomposite Material Alters Macrophage and Fibroblast Phenotype and Function following Myocardial Infarction: Relation to Left Ventricular Remodeling
Jeremy R. McGarvey, Sara Pettaway, James A. Shuman, Craig P. Novack, Kia N. Zellars, Parker D. Freels, Randall L. Echols, Jason A. Burdick, Joseph H. Gorman, Robert C. Gorman and Francis G. Spinale

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 701-709; DOI: https://doi.org/10.1124/jpet.114.215798

Cellular and Molecular

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Searching for Combinations of Small-Molecule Correctors to Restore F508del–Cystic Fibrosis Transmembrane Conductance Regulator Function and Processing
Clément Boinot, Mathilde Jollivet Souchet, Romain Ferru-Clément and Frédéric Becq

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 624-634; DOI: https://doi.org/10.1124/jpet.114.214890

Drug Discovery and Translational Medicine

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Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
Mikhail Kalinichev, Emmanuel Le Poul, Christelle Boléa, Françoise Girard, Brice Campo, Massimiliano Fonsi, Isabelle Royer-Urios, Susan E. Browne, Jason M. Uslaner, Matthew J. Davis, Jacob Raber, Robert Duvoisin, Simon T. Bate, Ian J. Reynolds, Sonia Poli and Sylvain Celanire

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 495-505; DOI: https://doi.org/10.1124/jpet.114.214437
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Vimocin and Vidapin, Cyclic KTS Peptides, Are Dual Antagonists of α₁β₁/α₂β₁ Integrins with Antiangiogenic Activity
Tatjana Momic, Jehoshua Katzehendler, Ofra Benny, Adi Lahiani, Gadi Cohen, Efrat Noy, Hanoch Senderowitz, Johannes A. Eble, Cezary Marcinkiewicz and Philip Lazarovici

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 506-519; DOI: https://doi.org/10.1124/jpet.114.214643
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NS19504: A Novel BK Channel Activator with Relaxing Effect on Bladder Smooth Muscle Spontaneous Phasic Contractions
Bernhard Nausch, Frederik Rode, Susanne Jørgensen, Antonio Nardi, Mads P. G. Korsgaard, Charlotte Hougaard, Adrian D. Bonev, William D. Brown, Tino Dyhring, Dorte Strøbæk, Søren-Peter Olesen, Palle Christophersen, Morten Grunnet, Mark T. Nelson and Lars C. B. Rønn

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 520-530; DOI: https://doi.org/10.1124/jpet.113.212662
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Tanshinone II A Sulfonate, but Not Tanshinone II A, Acts as Potent Negative Allosteric Modulator of the Human Purinergic Receptor P2X7
M. Kaiser, H. Sobottka, W. Fischer, M. Schaefer and W. Nörenberg

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 531-542; DOI: https://doi.org/10.1124/jpet.114.214569
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Clinically Relevant Doses of Candesartan Inhibit Growth of Prostate Tumor Xenografts In Vivo through Modulation of Tumor Angiogenesis
Ahmed Alhusban, Ahmad Al-Azayzih, Anna Goc, Fei Gao, Susan C. Fagan and Payaningal R. Somanath

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 635-645; DOI: https://doi.org/10.1124/jpet.114.216382
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DOT1L Inhibitor EPZ-5676 Displays Synergistic Antiproliferative Activity in Combination with Standard of Care Drugs and Hypomethylating Agents in MLL-Rearranged Leukemia Cells
Christine R. Klaus, Dorothy Iwanowicz, Danielle Johnston, Carly A. Campbell, Jesse J. Smith, Mikel P. Moyer, Robert A. Copeland, Edward J. Olhava, Margaret Porter Scott, Roy M. Pollock, Scott R. Daigle and Alejandra Raimondi

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 646-656; DOI: https://doi.org/10.1124/jpet.114.214577

Endocrine and Diabetes

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The Sodium Glucose Cotransporter Type 2 Inhibitor Empagliflozin Preserves β-Cell Mass and Restores Glucose Homeostasis in the Male Zucker Diabetic Fatty Rat
Henrik H. Hansen, Jacob Jelsing, Carl Frederik Hansen, Gitte Hansen, Niels Vrang, Michael Mark, Thomas Klein and Eric Mayoux

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 657-664; DOI: https://doi.org/10.1124/jpet.114.213454

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Characteristics of TRK-130 (Naltalimide), a Novel Opioid Ligand, as a New Therapeutic Agent for Overactive Bladder
Morihiro Fujimura, Naoki Izumimoto, Shinobu Momen, Satoru Yoshikawa, Ryosuke Kobayashi, Sayoko Kanie, Mikito Hirakata, Toshikazu Komagata, Satoshi Okanishi, Tadatoshi Hashimoto, Naoki Yoshimura and Koji Kawai

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 543-551; DOI: https://doi.org/10.1124/jpet.114.214031
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Astragaloside IV Ameliorates Renal Fibrosis via the Inhibition of Mitogen-Activated Protein Kinases and Antiapoptosis In Vivo and In Vitro
Weijia Xu, Xinghua Shao, Lei Tian, Leyi Gu, Minfang Zhang, Qin Wang, Bei Wu, Ling Wang, Jufang Yao, Xiaoping Xu, Shan Mou and Zhaohui Ni

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 552-562; DOI: https://doi.org/10.1124/jpet.114.214205
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The Guanosine-Adenosine Interaction Exists In Vivo
Edwin K. Jackson and Zaichuan Mi

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 719-726; DOI: https://doi.org/10.1124/jpet.114.216978

Inflammation, Immunopharmacology, and Asthma

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RhoA/Phosphatidylinositol 3-Kinase/Protein Kinase B/Mitogen-Activated Protein Kinase Signaling after Growth Arrest–Specific Protein 6/Mer Receptor Tyrosine Kinase Engagement Promotes Epithelial Cell Growth and Wound Repair via Upregulation of Hepatocyte Growth Factor in Macrophages
Ye-Ji Lee, Hyun-Jung Park, So-Youn Woo, Eun-Mi Park and Jihee Lee Kang

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 563-577; DOI: https://doi.org/10.1124/jpet.114.215673

Metabolism, Transport, and Pharmacogenomics

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Blood-Brain Barrier Pharmacoproteomics-Based Reconstruction of the In Vivo Brain Distribution of P-Glycoprotein Substrates in Cynomolgus Monkeys
Yasuo Uchida, Kentaro Wakayama, Sumio Ohtsuki, Masato Chiba, Tomoyuki Ohe, Yasuyuki Ishii and Tetsuya Terasaki

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 578-588; DOI: https://doi.org/10.1124/jpet.114.214536

Neuropharmacology

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Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
Kenji Maeda, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Jun Shimada, Takashi Futamura, Hiroshi Yamashita, Nobuaki Ito, Robert D. McQuade, Arne Mørk, Alan L. Pehrson, Morten Hentzer, Vibeke Nielsen, Christoffer Bundgaard, Jørn Arnt, Tine Bryan Stensbøl and Tetsuro Kikuchi

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 589-604; DOI: https://doi.org/10.1124/jpet.114.213793
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Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of a Novel Serotonin-Dopamine Activity Modulator
Kenji Maeda, Linda Lerdrup, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Robert D. McQuade, Tine Bryan Stensbøl, Christoffer Bundgaard, Jørn Arnt and Tetsuro Kikuchi

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 605-614; DOI: https://doi.org/10.1124/jpet.114.213819
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The Minimal Pharmacophore for Silent Agonism of the α₇ Nicotinic Acetylcholine Receptor
Roger L. Papke, Kinga Chojnacka and Nicole A. Horenstein

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 665-680; DOI: https://doi.org/10.1124/jpet.114.215236
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Pharmacologic Characterization in the Rat of a Potent Analgesic Lacking Respiratory Depression, IBNtxA
Steven G. Grinnell, Susruta Majumdar, Ankita Narayan, Valerie Le Rouzic, Michael Ansonoff, John E. Pintar and Gavril W. Pasternak

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 710-718; DOI: https://doi.org/10.1124/jpet.114.213199

Toxicology

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Gambierol Inhibition of Voltage-Gated Potassium Channels Augments Spontaneous Ca²⁺ Oscillations in Cerebrocortical Neurons
Zhengyu Cao, Yanjun Cui, Eric Busse, Suneet Mehrotra, Jon D. Rainier and Thomas F. Murray

Journal of Pharmacology and Experimental Therapeutics September 2014, 350 (3) 615-623; DOI: https://doi.org/10.1124/jpet.114.215319

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Table of Contents

Highlighted Papers

Commentary

Minireview

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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