Journal of Pharmacology and Experimental Therapeutics: 350 (2)

August 01, 2014; Volume 350,Issue 2

Highlighted Papers

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Circulating Protein Adducts in Diclofenac Patients
Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HI
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Casein Kinase II Regulates Synaptic Plasticity in Neuropathic Pain
Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HIa
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PHPB Attenuates Symptoms in a Mouse Model of Alzheimer’s Disease
Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HIb
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Structure and Pharmacodynamics of an Adnectin PCSK9 Inhibitor
Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 188; DOI: https://doi.org/10.1124/jpet.114.0814HIc

Perspectives in Pharmacology

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Repurposing Miltefosine for the Treatment of Immune-Mediated Disease?
Auke P. Verhaar, Manon E. Wildenberg, Maikel P. Peppelenbosch, Daniel W. Hommes and Gijs R. van den Brink

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 189-195; DOI: https://doi.org/10.1124/jpet.113.212654
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Animal Models That Best Reproduce the Clinical Manifestations of Human Intoxication with Organophosphorus Compounds
Edna F. R. Pereira, Yasco Aracava, Louis J. DeTolla, E. Jeffrey Beecham, G. William Basinger, Edgar J. Wakayama and Edson X. Albuquerque

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 313-321; DOI: https://doi.org/10.1124/jpet.114.214932

Behavioral Pharmacology

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Prolonged Monoacylglycerol Lipase Blockade Causes Equivalent Cannabinoid Receptor Type 1 Receptor–Mediated Adaptations in Fatty Acid Amide Hydrolase Wild-Type and Knockout Mice
Joel E. Schlosburg, Steven G. Kinsey, Bogna Ignatowska-Jankowska, Divya Ramesh, Rehab A. Abdullah, Qing Tao, Lamont Booker, Jonathan Z. Long, Dana E. Selley, Benjamin F. Cravatt and Aron H. Lichtman

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 196-204; DOI: https://doi.org/10.1124/jpet.114.212753
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Further Characterization of Quinpirole-Elicited Yawning as a Model of Dopamine D₃ Receptor Activation in Male and Female Monkeys
Susan E. Martelle, Susan H. Nader, Paul W. Czoty, William S. John, Angela N. Duke, Pradeep K. Garg, Sudha Garg, Amy H. Newman and Michael A. Nader

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 205-211; DOI: https://doi.org/10.1124/jpet.114.214833
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AZD9272 and AZD2066: Selective and Highly Central Nervous System Penetrant mGluR5 Antagonists Characterized by Their Discriminative Effects
Michael D. B. Swedberg and Patrick Raboisson

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 212-222; DOI: https://doi.org/10.1124/jpet.114.215137
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Different Contributions of Dopamine D1 and D2 Receptor Activity to Alcohol Potentiation of Brain Stimulation Reward in C57BL/6J and DBA/2J Mice
Eric W. Fish, Jeffrey F. DiBerto, Michael C. Krouse, J. Elliott Robinson and C. J. Malanga

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 322-329; DOI: https://doi.org/10.1124/jpet.114.216135
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Differential Substitution for the Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Methylphenidate in Rats
Tomohisa Mori, Naoki Uzawa, Haruyo Kazawa, Hirohiko Watanabe, Ayano Mochizuki, Masahiro Shibasaki, Kazumi Yoshizawa, Kimio Higashiyama and Tsutomu Suzuki

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 403-411; DOI: https://doi.org/10.1124/jpet.114.214288

Cardiovascular

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Prediction and Modeling of Effects on the QTc Interval for Clinical Safety Margin Assessment, Based on Single-Ascending-Dose Study Data with AZD3839
Erik Sparve, Angelica L. Quartino, Maria Lüttgen, Karin Tunblad, Anna Teiling Gårdlund, Johanna Fälting, Robert Alexander, Jens Kågström, Linnea Sjödin, Alexander Bulgak, Ahmad Al-Saffar, Matthew Bridgland-Taylor, Chris Pollard, Michael D. B. Swedberg, Torbjörn Vik and Björn Paulsson

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 469-478; DOI: https://doi.org/10.1124/jpet.114.215202

Cellular and Molecular

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Mouse Monoclonal Antibodies to Transient Receptor Potential Ankyrin 1 Act as Antagonists of Multiple Modes of Channel Activation
Ki Jeong Lee, Weiya Wang, Rupa Padaki, Vivian Bi, Cherylene A. Plewa and Narender R. Gavva

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 223-231; DOI: https://doi.org/10.1124/jpet.114.215574

Drug Discovery and Translational Medicine

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Novel Synthetic Toll-Like Receptor 4/MD2 Ligands Attenuate Sterile Inflammation
Tomoko Hayashi, Brian Crain, Shiyin Yao, Christa D. Caneda, Howard B. Cottam, Michael Chan, Maripat Corr and Dennis A. Carson

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 330-340; DOI: https://doi.org/10.1124/jpet.114.214312
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3,3′-Diindolylmethane Ameliorates Experimental Autoimmune Encephalomyelitis by Promoting Cell Cycle Arrest and Apoptosis in Activated T Cells through MicroRNA Signaling Pathways
Michael Rouse, Roshni Rao, Mitzi Nagarkatti and Prakash S. Nagarkatti

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 341-352; DOI: https://doi.org/10.1124/jpet.114.214742
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Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering
Tracy Mitchell, Ginger Chao, Doree Sitkoff, Fred Lo, Hossain Monshizadegan, Daniel Meyers, Simon Low, Katie Russo, Rose DiBella, Fabienne Denhez, Mian Gao, Joseph Myers, Gerald Duke, Mark Witmer, Bowman Miao, Siew P. Ho, Javed Khan and Rex A. Parker

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 412-424; DOI: https://doi.org/10.1124/jpet.114.214221

Endocrine and Diabetes

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Effect of LX4211 on Glucose Homeostasis and Body Composition in Preclinical Models
David R. Powell, Christopher M. DaCosta, Melinda Smith, Deon Doree, Angela Harris, Lindsey Buhring, William Heydorn, Amr Nouraldeen, Wendy Xiong, Padmaja Yalamanchili, Faika Mseeh, Alan Wilson, Melanie Shadoan, Brian Zambrowicz and Zhi-Ming Ding

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 232-242; DOI: https://doi.org/10.1124/jpet.114.214304
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The Novel GLP-1–Gastrin Dual Agonist ZP3022 Improves Glucose Homeostasis and Increases β-Cell Mass without Affecting Islet Number in db/db Mice
Louise S. Dalbøge, Dorthe L. C. Almholt, Trine S. R. Neerup, Niels Vrang, Jacob Jelsing and Keld Fosgerau

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 353-360; DOI: https://doi.org/10.1124/jpet.114.215293
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Maternal-Fetal Disposition of Glyburide in Pregnant Mice Is Dependent on Gestational Age
Diana L. Shuster, Linda J. Risler, Chao-Kang J. Liang, Kenneth M. Rice, Danny D. Shen, Mary F. Hebert, Kenneth E. Thummel and Qingcheng Mao

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 425-434; DOI: https://doi.org/10.1124/jpet.114.213470

Gastrointestinal, Hepatic, Pulmonary, and Renal

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Blocking Sirtuin 1 and 2 Inhibits Renal Interstitial Fibroblast Activation and Attenuates Renal Interstitial Fibrosis in Obstructive Nephropathy
Murugavel Ponnusamy, Xiaoxu Zhou, Yanli Yan, Jinhua Tang, Evelyn Tolbert, Ting C. Zhao, Rujun Gong and Shougang Zhuang

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 243-256; DOI: https://doi.org/10.1124/jpet.113.212076
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Agonism of the 5-Hydroxytryptamine 1F Receptor Promotes Mitochondrial Biogenesis and Recovery from Acute Kidney Injury
Sara M. Garrett, Ryan M. Whitaker, Craig C. Beeson and Rick G. Schnellmann

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 257-264; DOI: https://doi.org/10.1124/jpet.114.214700

Inflammation, Immunopharmacology, and Asthma

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Inhibitory Effect of Baicalin on Collagen-Induced Arthritis in Rats through the Nuclear Factor–κB Pathway
Hong-Zhi Wang, Hai-He Wang, Shi-Shun Huang, Hong Zhao, Yong-Gang Cao, Guang-Zhi Wang, Dong Wang, Zhi-Gang Wang and Yan-Hong Liu

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 435-443; DOI: https://doi.org/10.1124/jpet.114.215145
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Antiallergic and Antiasthmatic Effects of a Novel Enhydrazinone Ester (CEE-1): Inhibition of Activation of Both Mast Cells and Eosinophils
Charles I. Ezeamuzie, Ahmed Z. El-Hashim, Waleed M. Renno and Ivan O. Edafiogho

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 444-454; DOI: https://doi.org/10.1124/jpet.114.213751

Metabolism, Transport, and Pharmacogenomics

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Modeling and Simulation to Probe the Pharmacokinetic Disposition of Pomalidomide R- and S-Enantiomers
Yan Li, Simon Zhou, Matthew Hoffmann, Gondi Kumar and Maria Palmisano

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 265-272; DOI: https://doi.org/10.1124/jpet.114.215251

Neuropharmacology

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Novel N-Phenyl–Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity
Sina Oppermann, Florian C. Schrader, Katharina Elsässer, Amalia M. Dolga, Anna Lena Kraus, Nunzianna Doti, Christof Wegscheid-Gerlach, Martin Schlitzer and Carsten Culmsee

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 273-289; DOI: https://doi.org/10.1124/jpet.114.213777
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Sigma-1 Receptor Antagonism Restores Injury-Induced Decrease of Voltage-Gated Ca²⁺ Current in Sensory Neurons
Bin Pan, Yuan Guo, Wai-Meng Kwok, Quinn Hogan and Hsiang-en Wu

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 290-300; DOI: https://doi.org/10.1124/jpet.114.214320
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Casein Kinase II Regulates N-Methyl-d-Aspartate Receptor Activity in Spinal Cords and Pain Hypersensitivity Induced by Nerve Injury
Shao-Rui Chen, Hong-Yi Zhou, Hee Sun Byun, Hong Chen and Hui-Lin Pan

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 301-312; DOI: https://doi.org/10.1124/jpet.114.215855
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Potassium 2-(1-Hydroxypentyl)-Benzoate Improves Memory Deficits and Attenuates Amyloid and τ Pathologies in a Mouse Model of Alzheimer's Disease
Ying Peng, Yanli Hu, Shaofeng Xu, Xianfang Rong, Jiang Li, PingPing Li, Ling Wang, Jinghua Yang and Xiaoliang Wang

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 361-374; DOI: https://doi.org/10.1124/jpet.114.213140
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The [¹⁸F]FDG μPET Readout of a Brain Activation Model to Evaluate the Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator JNJ-42153605
Tine Wyckhuys, Leonie wyffels, Xavier Langlois, Mark Schmidt, Sigrid Stroobants and Steven Staelens

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 375-386; DOI: https://doi.org/10.1124/jpet.114.213959
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Characterization of RO5126946, a Novel α₇ Nicotinic Acetylcholine Receptor–Positive Allosteric Modulator
Sunil Sahdeo, Tanya Wallace, Ryoko Hirakawa, Frederic Knoflach, Daniel Bertrand, Hans Maag, Dinah Misner, Geoffrey C. Tombaugh, Luca Santarelli, Ken Brameld, Marcos E. Milla and Donald C. Button

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 455-468; DOI: https://doi.org/10.1124/jpet.113.210963

Toxicology

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Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients
Thomas G. Hammond, Xiaoli Meng, Rosalind E. Jenkins, James L. Maggs, Anahi Santoyo Castelazo, Sophie L. Regan, Stuart N. L. Bennett, Caroline J. Earnshaw, Guruprasad P. Aithal, Ira Pande, J. Gerry Kenna, Andrew V. Stachulski, B. Kevin Park and Dominic P. Williams

Journal of Pharmacology and Experimental Therapeutics August 2014, 350 (2) 387-402; DOI: https://doi.org/10.1124/jpet.114.215079

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Table of Contents

Highlighted Papers

Perspectives in Pharmacology

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Metabolism, Transport, and Pharmacogenomics

Neuropharmacology

Toxicology

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