PHPB [potassium 2-(1-hydroxypentyl)-benzoate] has been shown to have neuroprotective effects in animal models by inhibiting oxidative injury, neuronal apoptosis, and glial activation. The aim of the present study was to examine the effect of PHPB on learning and memory in amyloid precursor protein and presenilin 1 double-transgenic Alzheimer’s disease (AD) mouse models (APP/PS1). Twelve-month-old APP/PS1 mice were given 30 mg/kg PHPB by oral gavage for 3 months. PHPB treatment significantly improved the spatial learning and memory deficits compared to the vehicle-treated mice and reduced τ hyperphosphorylation at Ser199, Thr205, and Ser396 sites. In addition, the expressions of cyclin-dependent kinase and glycogen synthase kinase 3β, important kinases involved in τ phosphorylation, were markedly decreased. These data raised the possibility that PHPB might be a promising multitarget neuronal protective agent for the treatment of AD.
See article at J Pharmacol Exp Ther 2014, 350:361–374.
- Copyright © 2014 by The American Society for Pharmacology and Experimental Therapeutics