Journal of Pharmacology and Experimental Therapeutics: 349 (3)

June 01, 2014; Volume 349,Issue 3

Highlighted Papers

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Bryostatin-1 Restores Hippocampal Synapses, Learning, and Memory in Fragile X Mice
Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HI
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Histamine H₄-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion
Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HIa
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Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Intoxication
Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HIb
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Lubiprostone Prevents Nonsteroidal Anti-Inflammatory Drug–Induced Small Intestinal Damage via EP4 Receptors
Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 372; DOI: https://doi.org/10.1124/jpet.114.0614HIc

Behavioral Pharmacology

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Bryostatin-1 Restores Hippocampal Synapses and Spatial Learning and Memory in Adult Fragile X Mice
Miao-Kun Sun, Jarin Hongpaisan, Chol Seung Lim and Daniel L. Alkon

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 393-401; DOI: https://doi.org/10.1124/jpet.114.214098

Cardiovascular

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Histamine H₄-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion via Protein Kinase Cε-Dependent Aldehyde Dehydrogenase Type-2 Activation
Silvia Aldi, Ken-ichi Takano, Kengo Tomita, Kenichiro Koda, Noel Y.-K. Chan, Alice Marino, Mariselis Salazar-Rodriguez, Robin L. Thurmond and Roberto Levi

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 508-517; DOI: https://doi.org/10.1124/jpet.114.214122

Cellular and Molecular

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A Real-Time Method for Measuring cAMP Production Modulated by Gα_i/o-Coupled Metabotropic Glutamate Receptors
John O. DiRaddo, Eric J. Miller, Hannah A. Hathaway, Ewa Grajkowska, Barbara Wroblewska, Barry B. Wolfe, Dennis C. Liotta and Jarda T. Wroblewski

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 373-382; DOI: https://doi.org/10.1124/jpet.113.211532
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BAY60-6583 Acts as a Partial Agonist at Adenosine A_2B Receptors
Sonja Hinz, Svenja K. Lacher, Benjamin F. Seibt and Christa E. Müller

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 427-436; DOI: https://doi.org/10.1124/jpet.113.210849
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Activation of Estrogen Receptor α Enhances Bradykinin Signaling in Peripheral Sensory Neurons of Female Rats
Matthew P. Rowan, Kelly A. Berg, James L. Roberts, Kenneth M. Hargreaves and William P. Clarke

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 526-532; DOI: https://doi.org/10.1124/jpet.114.212977

Chemotherapy, Antibiotics, and Gene Therapy

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Rationale for Poly(ADP-ribose) Polymerase (PARP) Inhibitors in Combination Therapy with Camptothecins or Temozolomide Based on PARP Trapping versus Catalytic Inhibition
Junko Murai, Yiping Zhang, Joel Morris, Jiuping Ji, Shunichi Takeda, James H. Doroshow and Yves Pommier

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 408-416; DOI: https://doi.org/10.1124/jpet.113.210146
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Preclinical Characterization of Signal Transducer and Activator of Transcription 3 Small Molecule Inhibitors for Primary and Metastatic Brain Cancer Therapy
Hikmat H. Assi, Chris Paran, Nathan VanderVeen, Jonathan Savakus, Robert Doherty, Emanuele Petruzzella, James D. Hoeschele, Henry Appelman, Leda Raptis, Tom Mikkelsen, Pedro R. Lowenstein and Maria G. Castro

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 458-469; DOI: https://doi.org/10.1124/jpet.114.214619
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Investigation of Evolved Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Compound Intoxication
David G. Mata, Peter E. Rezk, Praveena Sabnekar, Douglas M. Cerasoli and Nageswararao Chilukuri

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 549-558; DOI: https://doi.org/10.1124/jpet.114.213645

Drug Discovery and Translational Medicine

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Identification of a Novel Small-Molecule Agonist for Human G Protein–Coupled Receptor 3
Chenli Ye, Zhenghong Zhang, Zhilong Wang, Qiuhong Hua, Ru Zhang and Xin Xie

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 437-443; DOI: https://doi.org/10.1124/jpet.114.213082
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Candesartan Induces a Prolonged Proangiogenic Effect and Augments Endothelium-Mediated Neuroprotection after Oxygen and Glucose Deprivation: Role of Vascular Endothelial Growth Factors A and B
Sahar Soliman, Tauheed Ishrat, Anilkumar Pillai, Payaningal R. Somanath, Adviye Ergul, Azza B. El-Remessy and Susan C. Fagan

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 444-457; DOI: https://doi.org/10.1124/jpet.113.212613
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Targeting the Myofibroblast Genetic Switch: Inhibitors of Myocardin-Related Transcription Factor/Serum Response Factor–Regulated Gene Transcription Prevent Fibrosis in a Murine Model of Skin Injury
Andrew J. Haak, Pei-Suen Tsou, Mohammad A. Amin, Jeffrey H. Ruth, Phillip Campbell, David A. Fox, Dinesh Khanna, Scott D. Larsen and Richard R. Neubig

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 480-486; DOI: https://doi.org/10.1124/jpet.114.213520
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A Monoclonal Antibody Specific for 6-Monoacetylmorphine Reduces Acute Heroin Effects in Mice
Inger Lise Bogen, Fernando Boix, Elisabeth Nerem, Jørg Mørland and Jannike Mørch Andersen

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 568-576; DOI: https://doi.org/10.1124/jpet.113.212035

Endocrine and Diabetes

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Treatment with the 3-Ketoacyl-CoA Thiolase Inhibitor Trimetazidine Does Not Exacerbate Whole-Body Insulin Resistance in Obese Mice
John R. Ussher, Wendy Keung, Natasha Fillmore, Timothy R. Koves, Jun Mori, Liyan Zhang, David G. Lopaschuk, Olga R. Ilkayeva, Cory S. Wagg, Jagdip S. Jaswal, Deborah M. Muoio and Gary D. Lopaschuk

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 487-496; DOI: https://doi.org/10.1124/jpet.114.214197

Gastrointestinal, Hepatic, Pulmonary, and Renal

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The Antifibrinolytic Drug Tranexamic Acid Reduces Liver Injury and Fibrosis in a Mouse Model of Chronic Bile Duct Injury
Nikita Joshi, Anna K. Kopec, Keara Towery, Kurt J. Williams and James P. Luyendyk

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 383-392; DOI: https://doi.org/10.1124/jpet.113.210880
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Effects of Duloxetine and WAY100635 on Pudendal Inhibition of Bladder Overactivity in Cats
Jeremy Reese, Zhiying Xiao, Zeyad Schwen, Yosuke Matsuta, Bing Shen, Jicheng Wang, James R. Roppolo, William C. de Groat and Changfeng Tai

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 402-407; DOI: https://doi.org/10.1124/jpet.113.211557
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Lubiprostone Prevents Nonsteroidal Anti-Inflammatory Drug–Induced Small Intestinal Damage by Suppressing the Expression of Inflammatory Mediators via EP4 Receptors
Shusaku Hayashi, Naoto Kurata, Aya Yamaguchi, Kikuko Amagase and Koji Takeuchi

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 470-479; DOI: https://doi.org/10.1124/jpet.114.213991
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The Water-Soluble Triptolide Derivative PG490-88 Protects against Cisplatin-Induced Acute Kidney Injury
Hyun-Jung Kim, Kameswaran Ravichandran, Abdullah Ozkok, Qian Wang, Zhibin He, Alkesh Jani, Danica Ljubanovic, Ivor S. Douglas and Charles L. Edelstein

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 518-525; DOI: https://doi.org/10.1124/jpet.114.213769

Inflammation, Immunopharmacology, and Asthma

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Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats
Yong Zhang, Xiaoguang Li, Qingwei Zhang, Jiamin Li, Jiaming Ju, Ning Du, Xin Liu, Xiaohui Chen, Feiran Cheng, Lei Yang, Chaoqian Xu, Muhammad U. Bilal, Yunwei Wei, Yanjie Lu and Baofeng Yang

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 417-426; DOI: https://doi.org/10.1124/jpet.114.212795

Neuropharmacology

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Rapid Transport of CCL11 across the Blood-Brain Barrier: Regional Variation and Importance of Blood Cells
Michelle A. Erickson, Yoichi Morofuji, Joshua B. Owen and William A. Banks

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 497-507; DOI: https://doi.org/10.1124/jpet.114.213074
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Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist
Klaus Linz, Thomas Christoph, Thomas M. Tzschentke, Thomas Koch, Klaus Schiene, Michael Gautrois, Wolfgang Schröder, Babette Y. Kögel, Horst Beier, Werner Englberger, Stefan Schunk, Jean De Vry, Ulrich Jahnel and Stefanie Frosch

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 535-548; DOI: https://doi.org/10.1124/jpet.114.213694
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Acute Ethanol Inhibits Dopamine Release in the Nucleus Accumbens via α6 Nicotinic Acetylcholine Receptors
Nathan D. Schilaty, David M. Hedges, Eun Young Jang, Ryan J. Folsom, Jordan T. Yorgason, J. Michael McIntosh and Scott C. Steffensen

Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 559-567; DOI: https://doi.org/10.1124/jpet.113.211490

Errata

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Correction to “A Novel Aminotetralin-Type Serotonin (5-HT) _2C Receptor-Specific Agonist and 5-HT_2A Competitive Antagonist/5-HT2B Inverse Agonist with Preclinical Efficacy for Psychoses”
Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 533; DOI: https://doi.org/10.1124/jpet.114.06er14
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Correction to “2-Isoxazol-3-Phenyltropane Derivatives of Cocaine: Molecular and Atypical System Effects at the Dopamine Transporter”
Journal of Pharmacology and Experimental Therapeutics June 2014, 349 (3) 534; DOI: https://doi.org/10.1124/jpet.114.06er14a

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Table of Contents

Highlighted Papers

Behavioral Pharmacology

Cardiovascular

Cellular and Molecular

Chemotherapy, Antibiotics, and Gene Therapy

Drug Discovery and Translational Medicine

Endocrine and Diabetes

Gastrointestinal, Hepatic, Pulmonary, and Renal

Inflammation, Immunopharmacology, and Asthma

Neuropharmacology

Errata

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