Journal of Pharmacology and Experimental Therapeutics: 329 (3)

June 01, 2009; Volume 329,Issue 3

HIGHLIGHTED PAPERS

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Cytochrome P450 Epoxygenase Inhibition for Cancer Therapy
Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 849;
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Potassium Channel Subunit Distribution Determines Ethanol Sensitivity
Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 849;

BEHAVIORAL PHARMACOLOGY

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Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Its Enantiomers in Mice: Pharmacokinetic Considerations
William E. Fantegrossi, Naoki Murai, Brian Ó. Mathúna, Nieves Pizarro and Rafael de la Torre

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1006-1015; DOI: https://doi.org/10.1124/jpet.109.150573
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Dissociation of the Effects of MTEP [3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on Conditioned Reinstatement and Reinforcement: Comparison between Cocaine and a Conventional Reinforcer
R. Martin-Fardon, M. A. S. Baptista, C. V. Dayas and F. Weiss

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1084-1090; DOI: https://doi.org/10.1124/jpet.109.151357

CARDIOVASCULAR

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Essential Role of the 90-Kilodalton Heat Shock Protein in Mediating Nongenomic Estrogen Signaling in Coronary Artery Smooth Muscle
Guichun Han, Handong Ma, Rajesh Chintala, David J. R. Fulton, Scott A. Barman and Richard E. White

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 850-855; DOI: https://doi.org/10.1124/jpet.108.149112
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The Protein Synthesis Inhibitor Anisomycin Induces Macrophage Apoptosis in Rabbit Atherosclerotic Plaques through p38 Mitogen-Activated Protein Kinase
Valerie Croons, Wim Martinet, Arnold G. Herman, Jean-Pierre Timmermans and Guido R. Y. De Meyer

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 856-864; DOI: https://doi.org/10.1124/jpet.108.149948
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Endothelin ET_B Receptors in Arteries and Veins: Multiple Actions in the Vein
Nathan R. Tykocki, Cheryl E. Gariepy and Stephanie W. Watts

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 875-881; DOI: https://doi.org/10.1124/jpet.108.145953
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Sepiapterin Decreases Acute Rejection and Apoptosis in Cardiac Transplants Independently of Changes in Nitric Oxide and Inducible Nitric-Oxide Synthase Dimerization
Galen M. Pieper, Irina A. Ionova, Brian C. Cooley, Raymond Q. Migrino, Ashwani K. Khanna, Jennifer Whitsett and Jeannette Vásquez-Vivar

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 890-899; DOI: https://doi.org/10.1124/jpet.108.148569
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Erythropoietin Protects the Heart from Ventricular Arrhythmia during Ischemia and Reperfusion via Neuronal Nitric-Oxide Synthase
Dylan E. Burger, Fu-Li Xiang, Lamis Hammoud, Douglas L. Jones and Qingping Feng

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 900-907; DOI: https://doi.org/10.1124/jpet.109.150896
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Inhibition of Vascular Smooth-Muscle Cell Proliferation and Arterial Restenosis by HO-3867, a Novel Synthetic Curcuminoid, through Up-Regulation of PTEN Expression
Karuppaiyah Selvendiran, M. Lakshmi Kuppusamy, Anna Bratasz, Liyue Tong, Brian K. Rivera, Cameron Rink, Chandan K. Sen, Tamás Kálai, Kálmán Hideg and Periannan Kuppusamy

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 959-966; DOI: https://doi.org/10.1124/jpet.108.150367
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Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the Kidneys
Min Xia, Li Chen, Rachel W. Muh, Pin-Lan Li and Ningjun Li

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1056-1062; DOI: https://doi.org/10.1124/jpet.108.149963
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The Gap Junction Modifier, GAP-134 [(2S,4R)-1-(2-Aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic Acid], Improves Conduction and Reduces Atrial Fibrillation/Flutter in the Canine Sterile Pericarditis Model
Eric I. Rossman, Kun Liu, Gwen A. Morgan, Robert E. Swillo, Julie A. Krueger, Stephen J. Gardell, John Butera, Matthew Gruver, Joel Kantrowitz, Hal S. Feldman, Jørgen S. Petersen, Ketil Haugan and James K. Hennan

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1127-1133; DOI: https://doi.org/10.1124/jpet.108.150102
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The Ceiling Effect of Pharmacological Postconditioning with the Phytoestrogen Genistein Is Reversed by the GSK3β Inhibitor SB 216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through Mitochondrial ATP-Dependent Potassium Channel Opening
Nicolas Couvreur, Renaud Tissier, Sandrine Pons, Mourad Chenoune, Xavier Waintraub, Alain Berdeaux and Bijan Ghaleh

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1134-1141; DOI: https://doi.org/10.1124/jpet.109.152587
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Characterization of Mouse Heart Adenylyl Cyclase
Martin Göttle, Jens Geduhn, Burkhard König, Andreas Gille, Klaus Höcherl and Roland Seifert

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1156-1165; DOI: https://doi.org/10.1124/jpet.109.150953

CELLULAR AND MOLECULAR

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Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor
Cynthia M. Rominger, Wei-Lin Tiger Bee, Robert A. Copeland, Elizabeth A. Davenport, Aidan Gilmartin, Richard Gontarek, Keith R. Hornberger, Lorena A. Kallal, Zhihong Lai, Kenneth Lawrie, Quinn Lu, Lynette McMillan, Maggie Truong, Peter J. Tummino, Brandon Turunen, Matthew Will, William J. Zuercher and David H. Rominger

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 995-1005; DOI: https://doi.org/10.1124/jpet.109.152090
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Resistance to Mitogen-Activated Protein Kinase Kinase (MEK) Inhibitors Correlates with Up-Regulation of the MEK/Extracellular Signal-Regulated Kinase Pathway in Hepatocellular Carcinoma Cells
Michele T. Yip-Schneider, Patrick J. Klein, Sabrina C. Wentz, Amer Zeni, Alex Menze and C. Max Schmidt

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1063-1070; DOI: https://doi.org/10.1124/jpet.108.147306

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo
Chen Chen, Guiling Li, Wanmin Liao, Jun Wu, Liu Liu, Ding Ma, Jianfeng Zhou, Reem H. Elbekai, Matthew L. Edin, Darryl C. Zeldin and Dao Wen Wang

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 908-918; DOI: https://doi.org/10.1124/jpet.109.152017
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Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious Rats and Mice: Reversal with Antihypertensive Agents and Effect on Tumor Growth Inhibition
Pamela H. Franklin, Patricia N. Banfor, Paul Tapang, Jason A. Segreti, Deborah L. Widomski, Kelly J. Larson, William T. Noonan, Gary A. Gintant, Steven K. Davidsen, Daniel H. Albert, Ryan M. Fryer and Bryan F. Cox

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 928-937; DOI: https://doi.org/10.1124/jpet.108.144816

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Hindlimb Ischemia/Reperfusion-Induced Remote Injury to the Small Intestine: Role of Inducible Nitric-Oxide Synthase-Derived Nitric Oxide
Kazuhiro Katada, Aurelia Bihari, Amit Badhwar, Norimasa Yoshida, Toshikazu Yoshikawa, Richard F. Potter and Gediminas Cepinskas

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 919-927; DOI: https://doi.org/10.1124/jpet.108.148460
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Oats Supplementation Prevents Alcohol-Induced Gut Leakiness in Rats by Preventing Alcohol-Induced Oxidative Tissue Damage
Yueming Tang, Christopher B. Forsyth, Ali Banan, Jeremy Z. Fields and Ali Keshavarzian

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 952-958; DOI: https://doi.org/10.1124/jpet.108.148643
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The Selective 5-Hydroxytryptamine 1A Antagonist, AZD7371 [3(R)-(N,N-Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide (R,R)-tartrate Monohydrate] (Robalzotan Tartrate Monohydrate), Inhibits Visceral Pain-Related Visceromotor, but Not Autonomic Cardiovascular, Responses to Colorectal Distension in Rats
E. Lindström, A. Ravnefjord, M. Brusberg, S. Hjorth, H. Larsson and V. Martinez

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1048-1055; DOI: https://doi.org/10.1124/jpet.109.152330
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Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus
Kalina Venkova, William Mann, Richard Nelson and Beverley Greenwood-Van Meerveld

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1110-1116; DOI: https://doi.org/10.1124/jpet.108.149211
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Effect of Hydrogen Sulfide on the Phosphatidylinositol 3-Kinase-Protein Kinase B Pathway and on Caerulein-Induced Cytokine Production in Isolated Mouse Pancreatic Acinar Cells
Ramasamy Tamizhselvi, Jia Sun, Yung-Hua Koh and Madhav Bhatia

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1166-1177; DOI: https://doi.org/10.1124/jpet.109.150532
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Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists
Soratree Charoenthongtrakul, Derek Giuliana, Kenneth A. Longo, Elizabeth K. Govek, Anna Nolan, Samantha Gagne, Kristen Morgan, Jeffrey Hixon, Neil Flynn, Brian J. Murphy, Andres S. Hernández, Jun Li, Joseph A. Tino, David A. Gordon, Peter S. DiStefano and Brad J. Geddes

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1178-1186; DOI: https://doi.org/10.1124/jpet.108.150193

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Noninvasive Quantitative Tomography of the Therapeutic Response to Dexamethasone in Ovalbumin-Induced Murine Asthma
Houari Korideck and Jeffrey D. Peterson

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 882-889; DOI: https://doi.org/10.1124/jpet.108.147579
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Cyclooxygenase-2 Induced by Zymosan in Human Monocyte-Derived Dendritic Cells Shows High Stability, and Its Expression Is Enhanced by Atorvastatin
Yolanda Alvarez, Cristina Municio, Sara Alonso, José Alberto San Román, Mariano Sánchez Crespo and Nieves Fernández

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 987-994; DOI: https://doi.org/10.1124/jpet.108.149336
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Evidence for the Nucleus Accumbens as a Neural Substrate of Heroin-Induced Immune Alterations
Timothy B. Saurer, Stephanie G. Ijames and Donald T. Lysle

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1040-1047; DOI: https://doi.org/10.1124/jpet.108.148627
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An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis
Halina Offner, Gary S. Firestein, David L. Boyle, Raymond Pieters, James M. Frincke, Armando Garsd, Steven K. White, Christopher L. Reading and Dominick L. Auci

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1100-1109; DOI: https://doi.org/10.1124/jpet.108.145086
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Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor-Expressing Endothelial Cells Exhibit Reduced Migration and Stimulated Chemotaxis by Chemokine Inverse Agonists
Jean-Pierre Couty, Monica Lupu-Meiri, Yoram Oron and Marvin C. Gershengorn

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1142-1147; DOI: https://doi.org/10.1124/jpet.108.147686

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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CYP2C9 Amino Acid Residues Influencing Phenytoin Turnover and Metabolite Regio- and Stereochemistry
Carrie M. Mosher, Guoying Tai and Allan E. Rettie

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 938-944; DOI: https://doi.org/10.1124/jpet.109.150706
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As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina
Huixia Zhang, Xiaohui Wu, Francisco Chung, Suresh Babu Naraharisetti, Dale Whittington, Ahmad Mirfazaelian and Jashvant D. Unadkat

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1016-1022; DOI: https://doi.org/10.1124/jpet.109.151746
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Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities
Stephen W. J. Wang, Kaustubh H. Kulkarni, Lan Tang, Jing Rong Wang, Taijun Yin, Tomo Daidoji, Hiroshi Yokota and Ming Hu

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1023-1031; DOI: https://doi.org/10.1124/jpet.108.147371
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The Effect of Allelic Variation in Aldo-Keto Reductase 1C2 on the in Vitro Metabolism of Dihydrotestosterone
Ryan H. Takahashi, Thomas A. Grigliatti, Ronald E. Reid and K. Wayne Riggs

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1032-1039; DOI: https://doi.org/10.1124/jpet.109.150995
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Differential Localization of Flavin-Containing Monooxygenase (FMO) Isoforms 1, 3, and 4 in Rat Liver and Kidney and Evidence for Expression of FMO4 in Mouse, Rat, and Human Liver and Kidney Microsomes
Rachel M. Novick, Ann M. Mitzey, Mark S. Brownfield and Adnan A. Elfarra

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1148-1155; DOI: https://doi.org/10.1124/jpet.109.152058

NEUROPHARMACOLOGY

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The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells
Kiyoshi Kikuchi, Ko-ichi Kawahara, Salunya Tancharoen, Fumiyo Matsuda, Yoko Morimoto, Takashi Ito, Kamal Krishna Biswas, Kazunori Takenouchi, Naoki Miura, Yoko Oyama, Yuko Nawa, Noboru Arimura, Masahiro Iwata, Yutaka Tajima, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori, Yoshihiro Yoshida, Teruto Hashiguchi and Ikuro Maruyama

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 865-874; DOI: https://doi.org/10.1124/jpet.108.149484
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Scratching Behavior and Fos Expression in Superficial Dorsal Horn Elicited by Protease-Activated Receptor Agonists and Other Itch Mediators in Mice
Tasuku Akiyama, Austin W. Merrill, Karen Zanotto, Mirela Iodi Carstens and E. Carstens

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 945-951; DOI: https://doi.org/10.1124/jpet.109.152256
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Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein
Lisa Sanderson, Murat Dogruel, Jean Rodgers, Harry Pieter De Koning and Sarah Ann Thomas

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 967-977; DOI: https://doi.org/10.1124/jpet.108.149872
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Compartmentalized β Subunit Distribution Determines Characteristics and Ethanol Sensitivity of Somatic, Dendritic, and Terminal Large-Conductance Calcium-Activated Potassium Channels in the Rat Central Nervous System
P. M. Wynne, S. I. Puig, G. E. Martin and S. N. Treistman

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 978-986; DOI: https://doi.org/10.1124/jpet.108.146175
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HIV-1 Tat Protein-Induced Rapid and Reversible Decrease in [³H]Dopamine Uptake: Dissociation of [³H]Dopamine Uptake and [³H]2β-Carbomethoxy-3-β-(4-fluorophenyl)tropane (WIN 35,428) Binding in Rat Striatal Synaptosomes
Jun Zhu, Charles F. Mactutus, David R. Wallace and Rosemarie M. Booze

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1071-1083; DOI: https://doi.org/10.1124/jpet.108.150144
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Activation of Group I Metabotropic Glutamate Receptors Increases Serine Phosphorylation of GluR1 α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptors in the Rat Dorsal Striatum
Sung Min Ahn and Eun Sang Choe

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1117-1126; DOI: https://doi.org/10.1124/jpet.108.149542

TOXICOLOGY

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Maternal Exposure to Dioxin Disrupts Gonadotropin Production in Fetal Rats and Imprints Defects in Sexual Behavior
Tomoki Takeda, Yuki Matsumoto, Takayuki Koga, Junpei Mutoh, Yoshio Nishimura, Takao Shimazoe, Yuji Ishii, Takumi Ishida and Hideyuki Yamada

Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1091-1099; DOI: https://doi.org/10.1124/jpet.109.151282

Errata

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Correction to “Regulation of Somatostatin Release by Adenosine in the Mouse Stomach”
Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1187;
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Correction to “Transport of Lamivudine [(-)-β-l-2′,3′-Dideoxy-3′-thiacytidine] and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors with Human Organic Cation Transporters 1, 2, and 3”
Journal of Pharmacology and Experimental Therapeutics June 2009, 329 (3) 1187;

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Table of Contents

HIGHLIGHTED PAPERS

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

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