Table of Contents

June 2009; 329 (3)

HIGHLIGHTED PAPERS

  • Cytochrome P450 Epoxygenase Inhibition for Cancer Therapy

    J Pharmacol Exp Ther June 2009 329:849

  • Potassium Channel Subunit Distribution Determines Ethanol Sensitivity

    J Pharmacol Exp Ther June 2009 329:849

CARDIOVASCULAR

    • Guichun Han,
    • Handong Ma,
    • Rajesh Chintala,
    • David J. R. Fulton,
    • Scott A. Barman,
    • and Richard E. White

    Essential Role of the 90-Kilodalton Heat Shock Protein in Mediating Nongenomic Estrogen Signaling in Coronary Artery Smooth Muscle

    J Pharmacol Exp Ther June 2009 329:850-855; published ahead of print March 17, 2009, doi:10.1124/jpet.108.149112
    • Valerie Croons,
    • Wim Martinet,
    • Arnold G. Herman,
    • Jean-Pierre Timmermans,
    • and Guido R. Y. De Meyer

    The Protein Synthesis Inhibitor Anisomycin Induces Macrophage Apoptosis in Rabbit Atherosclerotic Plaques through p38 Mitogen-Activated Protein Kinase

    J Pharmacol Exp Ther June 2009 329:856-864; published ahead of print March 13, 2009, doi:10.1124/jpet.108.149948
    • Nathan R. Tykocki,
    • Cheryl E. Gariepy,
    • and Stephanie W. Watts

    Endothelin ETB Receptors in Arteries and Veins: Multiple Actions in the Vein

    J Pharmacol Exp Ther June 2009 329:875-881; published ahead of print March 18, 2009, doi:10.1124/jpet.108.145953
    • Galen M. Pieper,
    • Irina A. Ionova,
    • Brian C. Cooley,
    • Raymond Q. Migrino,
    • Ashwani K. Khanna,
    • Jennifer Whitsett,
    • and Jeannette Vásquez-Vivar

    Sepiapterin Decreases Acute Rejection and Apoptosis in Cardiac Transplants Independently of Changes in Nitric Oxide and Inducible Nitric-Oxide Synthase Dimerization

    J Pharmacol Exp Ther June 2009 329:890-899; published ahead of print March 23, 2009, doi:10.1124/jpet.108.148569
    • Dylan E. Burger,
    • Fu-Li Xiang,
    • Lamis Hammoud,
    • Douglas L. Jones,
    • and Qingping Feng

    Erythropoietin Protects the Heart from Ventricular Arrhythmia during Ischemia and Reperfusion via Neuronal Nitric-Oxide Synthase

    J Pharmacol Exp Ther June 2009 329:900-907; published ahead of print March 23, 2009, doi:10.1124/jpet.109.150896
    • Karuppaiyah Selvendiran,
    • M. Lakshmi Kuppusamy,
    • Anna Bratasz,
    • Liyue Tong,
    • Brian K. Rivera,
    • Cameron Rink,
    • Chandan K. Sen,
    • Tamás Kálai,
    • Kálmán Hideg,
    • and Periannan Kuppusamy

    Inhibition of Vascular Smooth-Muscle Cell Proliferation and Arterial Restenosis by HO-3867, a Novel Synthetic Curcuminoid, through Up-Regulation of PTEN Expression

    J Pharmacol Exp Ther June 2009 329:959-966; published ahead of print March 10, 2009, doi:10.1124/jpet.108.150367
    • Min Xia,
    • Li Chen,
    • Rachel W. Muh,
    • Pin-Lan Li,
    • and Ningjun Li

    Production and Actions of Hydrogen Sulfide, a Novel Gaseous Bioactive Substance, in the Kidneys

    J Pharmacol Exp Ther June 2009 329:1056-1062; published ahead of print February 26, 2009, doi:10.1124/jpet.108.149963
    • Eric I. Rossman,
    • Kun Liu,
    • Gwen A. Morgan,
    • Robert E. Swillo,
    • Julie A. Krueger,
    • Stephen J. Gardell,
    • John Butera,
    • Matthew Gruver,
    • Joel Kantrowitz,
    • Hal S. Feldman,
    • Jørgen S. Petersen,
    • Ketil Haugan,
    • and James K. Hennan

    The Gap Junction Modifier, GAP-134 [(2S,4R)-1-(2-Aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic Acid], Improves Conduction and Reduces Atrial Fibrillation/Flutter in the Canine Sterile Pericarditis Model

    J Pharmacol Exp Ther June 2009 329:1127-1133; published ahead of print February 27, 2009, doi:10.1124/jpet.108.150102
    • Nicolas Couvreur,
    • Renaud Tissier,
    • Sandrine Pons,
    • Mourad Chenoune,
    • Xavier Waintraub,
    • Alain Berdeaux,
    • and Bijan Ghaleh

    The Ceiling Effect of Pharmacological Postconditioning with the Phytoestrogen Genistein Is Reversed by the GSK3β Inhibitor SB 216763 [3-(2,4-Dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through Mitochondrial ATP-Dependent Potassium Channel Opening

    J Pharmacol Exp Ther June 2009 329:1134-1141; published ahead of print March 24, 2009, doi:10.1124/jpet.109.152587
    • Martin Göttle,
    • Jens Geduhn,
    • Burkhard König,
    • Andreas Gille,
    • Klaus Höcherl,
    • and Roland Seifert

    Characterization of Mouse Heart Adenylyl Cyclase

    J Pharmacol Exp Ther June 2009 329:1156-1165; published ahead of print March 23, 2009, doi:10.1124/jpet.109.150953

NEUROPHARMACOLOGY

    • Kiyoshi Kikuchi,
    • Ko-ichi Kawahara,
    • Salunya Tancharoen,
    • Fumiyo Matsuda,
    • Yoko Morimoto,
    • Takashi Ito,
    • Kamal Krishna Biswas,
    • Kazunori Takenouchi,
    • Naoki Miura,
    • Yoko Oyama,
    • Yuko Nawa,
    • Noboru Arimura,
    • Masahiro Iwata,
    • Yutaka Tajima,
    • Terukazu Kuramoto,
    • Kenji Nakayama,
    • Minoru Shigemori,
    • Yoshihiro Yoshida,
    • Teruto Hashiguchi,
    • and Ikuro Maruyama

    The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells

    J Pharmacol Exp Ther June 2009 329:865-874; published ahead of print March 17, 2009, doi:10.1124/jpet.108.149484
    • Tasuku Akiyama,
    • Austin W. Merrill,
    • Karen Zanotto,
    • Mirela Iodi Carstens,
    • and E. Carstens

    Scratching Behavior and Fos Expression in Superficial Dorsal Horn Elicited by Protease-Activated Receptor Agonists and Other Itch Mediators in Mice

    J Pharmacol Exp Ther June 2009 329:945-951; published ahead of print March 17, 2009, doi:10.1124/jpet.109.152256
    • Lisa Sanderson,
    • Murat Dogruel,
    • Jean Rodgers,
    • Harry Pieter De Koning,
    • and Sarah Ann Thomas

    Pentamidine Movement across the Murine Blood-Brain and Blood-Cerebrospinal Fluid Barriers: Effect of Trypanosome Infection, Combination Therapy, P-Glycoprotein, and Multidrug Resistance-Associated Protein

    J Pharmacol Exp Ther June 2009 329:967-977; published ahead of print March 4, 2009, doi:10.1124/jpet.108.149872
    • P. M. Wynne,
    • S. I. Puig,
    • G. E. Martin,
    • and S. N. Treistman

    Compartmentalized β Subunit Distribution Determines Characteristics and Ethanol Sensitivity of Somatic, Dendritic, and Terminal Large-Conductance Calcium-Activated Potassium Channels in the Rat Central Nervous System

    J Pharmacol Exp Ther June 2009 329:978-986; published ahead of print March 25, 2009, doi:10.1124/jpet.108.146175
    • Jun Zhu,
    • Charles F. Mactutus,
    • David R. Wallace,
    • and Rosemarie M. Booze

    HIV-1 Tat Protein-Induced Rapid and Reversible Decrease in [3H]Dopamine Uptake: Dissociation of [3H]Dopamine Uptake and [3H]2β-Carbomethoxy-3-β-(4-fluorophenyl)tropane (WIN 35,428) Binding in Rat Striatal Synaptosomes

    J Pharmacol Exp Ther June 2009 329:1071-1083; published ahead of print March 26, 2009, doi:10.1124/jpet.108.150144
    • Sung Min Ahn and
    • Eun Sang Choe

    Activation of Group I Metabotropic Glutamate Receptors Increases Serine Phosphorylation of GluR1 α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptors in the Rat Dorsal Striatum

    J Pharmacol Exp Ther June 2009 329:1117-1126; published ahead of print March 3, 2009, doi:10.1124/jpet.108.149542

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

    • Houari Korideck and
    • Jeffrey D. Peterson

    Noninvasive Quantitative Tomography of the Therapeutic Response to Dexamethasone in Ovalbumin-Induced Murine Asthma

    J Pharmacol Exp Ther June 2009 329:882-889; published ahead of print March 17, 2009, doi:10.1124/jpet.108.147579
    • Yolanda Alvarez,
    • Cristina Municio,
    • Sara Alonso,
    • José Alberto San Román,
    • Mariano Sánchez Crespo,
    • and Nieves Fernández

    Cyclooxygenase-2 Induced by Zymosan in Human Monocyte-Derived Dendritic Cells Shows High Stability, and Its Expression Is Enhanced by Atorvastatin

    J Pharmacol Exp Ther June 2009 329:987-994; published ahead of print March 24, 2009, doi:10.1124/jpet.108.149336
    • Timothy B. Saurer,
    • Stephanie G. Ijames,
    • and Donald T. Lysle

    Evidence for the Nucleus Accumbens as a Neural Substrate of Heroin-Induced Immune Alterations

    J Pharmacol Exp Ther June 2009 329:1040-1047; published ahead of print March 3, 2009, doi:10.1124/jpet.108.148627
    • Halina Offner,
    • Gary S. Firestein,
    • David L. Boyle,
    • Raymond Pieters,
    • James M. Frincke,
    • Armando Garsd,
    • Steven K. White,
    • Christopher L. Reading,
    • and Dominick L. Auci

    An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis

    J Pharmacol Exp Ther June 2009 329:1100-1109; published ahead of print March 18, 2009, doi:10.1124/jpet.108.145086
    • Jean-Pierre Couty,
    • Monica Lupu-Meiri,
    • Yoram Oron,
    • and Marvin C. Gershengorn

    Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor-Expressing Endothelial Cells Exhibit Reduced Migration and Stimulated Chemotaxis by Chemokine Inverse Agonists

    J Pharmacol Exp Ther June 2009 329:1142-1147; published ahead of print March 3, 2009, doi:10.1124/jpet.108.147686

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

    • Chen Chen,
    • Guiling Li,
    • Wanmin Liao,
    • Jun Wu,
    • Liu Liu,
    • Ding Ma,
    • Jianfeng Zhou,
    • Reem H. Elbekai,
    • Matthew L. Edin,
    • Darryl C. Zeldin,
    • and Dao Wen Wang

    Selective Inhibitors of CYP2J2 Related to Terfenadine Exhibit Strong Activity against Human Cancers in Vitro and in Vivo

    J Pharmacol Exp Ther June 2009 329:908-918; published ahead of print March 16, 2009, doi:10.1124/jpet.109.152017
    • Pamela H. Franklin,
    • Patricia N. Banfor,
    • Paul Tapang,
    • Jason A. Segreti,
    • Deborah L. Widomski,
    • Kelly J. Larson,
    • William T. Noonan,
    • Gary A. Gintant,
    • Steven K. Davidsen,
    • Daniel H. Albert,
    • Ryan M. Fryer,
    • and Bryan F. Cox

    Effect of the Multitargeted Receptor Tyrosine Kinase Inhibitor, ABT-869 [N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N′-(2-fluoro-5-methylphenyl)urea], on Blood Pressure in Conscious Rats and Mice: Reversal with Antihypertensive Agents and Effect on Tumor Growth Inhibition

    J Pharmacol Exp Ther June 2009 329:928-937; published ahead of print March 2, 2009, doi:10.1124/jpet.108.144816

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

    • Kazuhiro Katada,
    • Aurelia Bihari,
    • Amit Badhwar,
    • Norimasa Yoshida,
    • Toshikazu Yoshikawa,
    • Richard F. Potter,
    • and Gediminas Cepinskas

    Hindlimb Ischemia/Reperfusion-Induced Remote Injury to the Small Intestine: Role of Inducible Nitric-Oxide Synthase-Derived Nitric Oxide

    J Pharmacol Exp Ther June 2009 329:919-927; published ahead of print March 6, 2009, doi:10.1124/jpet.108.148460
    • Yueming Tang,
    • Christopher B. Forsyth,
    • Ali Banan,
    • Jeremy Z. Fields,
    • and Ali Keshavarzian

    Oats Supplementation Prevents Alcohol-Induced Gut Leakiness in Rats by Preventing Alcohol-Induced Oxidative Tissue Damage

    J Pharmacol Exp Ther June 2009 329:952-958; published ahead of print March 10, 2009, doi:10.1124/jpet.108.148643
    • E. Lindström,
    • A. Ravnefjord,
    • M. Brusberg,
    • S. Hjorth,
    • H. Larsson,
    • and V. Martinez

    The Selective 5-Hydroxytryptamine 1A Antagonist, AZD7371 [3(R)-(N,N-Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide (R,R)-tartrate Monohydrate] (Robalzotan Tartrate Monohydrate), Inhibits Visceral Pain-Related Visceromotor, but Not Autonomic Cardiovascular, Responses to Colorectal Distension in Rats

    J Pharmacol Exp Ther June 2009 329:1048-1055; published ahead of print March 26, 2009, doi:10.1124/jpet.109.152330
    • Kalina Venkova,
    • William Mann,
    • Richard Nelson,
    • and Beverley Greenwood-Van Meerveld

    Efficacy of Ipamorelin, a Novel Ghrelin Mimetic, in a Rodent Model of Postoperative Ileus

    J Pharmacol Exp Ther June 2009 329:1110-1116; published ahead of print March 16, 2009, doi:10.1124/jpet.108.149211
    • Ramasamy Tamizhselvi,
    • Jia Sun,
    • Yung-Hua Koh,
    • and Madhav Bhatia

    Effect of Hydrogen Sulfide on the Phosphatidylinositol 3-Kinase-Protein Kinase B Pathway and on Caerulein-Induced Cytokine Production in Isolated Mouse Pancreatic Acinar Cells

    J Pharmacol Exp Ther June 2009 329:1166-1177; published ahead of print March 3, 2009, doi:10.1124/jpet.109.150532
    • Soratree Charoenthongtrakul,
    • Derek Giuliana,
    • Kenneth A. Longo,
    • Elizabeth K. Govek,
    • Anna Nolan,
    • Samantha Gagne,
    • Kristen Morgan,
    • Jeffrey Hixon,
    • Neil Flynn,
    • Brian J. Murphy,
    • Andres S. Hernández,
    • Jun Li,
    • Joseph A. Tino,
    • David A. Gordon,
    • Peter S. DiStefano,
    • and Brad J. Geddes

    Enhanced Gastrointestinal Motility with Orally Active Ghrelin Receptor Agonists

    J Pharmacol Exp Ther June 2009 329:1178-1186; published ahead of print February 27, 2009, doi:10.1124/jpet.108.150193

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

    • Carrie M. Mosher,
    • Guoying Tai,
    • and Allan E. Rettie

    CYP2C9 Amino Acid Residues Influencing Phenytoin Turnover and Metabolite Regio- and Stereochemistry

    J Pharmacol Exp Ther June 2009 329:938-944; published ahead of print March 3, 2009, doi:10.1124/jpet.109.150706
    • Huixia Zhang,
    • Xiaohui Wu,
    • Francisco Chung,
    • Suresh Babu Naraharisetti,
    • Dale Whittington,
    • Ahmad Mirfazaelian,
    • and Jashvant D. Unadkat

    As in Humans, Pregnancy Increases the Clearance of the Protease Inhibitor Nelfinavir in the Nonhuman Primate Macaca nemestrina

    J Pharmacol Exp Ther June 2009 329:1016-1022; published ahead of print March 17, 2009, doi:10.1124/jpet.109.151746
    • Stephen W. J. Wang,
    • Kaustubh H. Kulkarni,
    • Lan Tang,
    • Jing Rong Wang,
    • Taijun Yin,
    • Tomo Daidoji,
    • Hiroshi Yokota,
    • and Ming Hu

    Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities

    J Pharmacol Exp Ther June 2009 329:1023-1031; published ahead of print March 5, 2009, doi:10.1124/jpet.108.147371
    • Ryan H. Takahashi,
    • Thomas A. Grigliatti,
    • Ronald E. Reid,
    • and K. Wayne Riggs

    The Effect of Allelic Variation in Aldo-Keto Reductase 1C2 on the in Vitro Metabolism of Dihydrotestosterone

    J Pharmacol Exp Ther June 2009 329:1032-1039; published ahead of print March 3, 2009, doi:10.1124/jpet.109.150995
    • Rachel M. Novick,
    • Ann M. Mitzey,
    • Mark S. Brownfield,
    • and Adnan A. Elfarra

    Differential Localization of Flavin-Containing Monooxygenase (FMO) Isoforms 1, 3, and 4 in Rat Liver and Kidney and Evidence for Expression of FMO4 in Mouse, Rat, and Human Liver and Kidney Microsomes

    J Pharmacol Exp Ther June 2009 329:1148-1155; published ahead of print March 23, 2009, doi:10.1124/jpet.109.152058

CELLULAR AND MOLECULAR

    • Cynthia M. Rominger,
    • Wei-Lin Tiger Bee,
    • Robert A. Copeland,
    • Elizabeth A. Davenport,
    • Aidan Gilmartin,
    • Richard Gontarek,
    • Keith R. Hornberger,
    • Lorena A. Kallal,
    • Zhihong Lai,
    • Kenneth Lawrie,
    • Quinn Lu,
    • Lynette McMillan,
    • Maggie Truong,
    • Peter J. Tummino,
    • Brandon Turunen,
    • Matthew Will,
    • William J. Zuercher,
    • and David H. Rominger

    Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor

    J Pharmacol Exp Ther June 2009 329:995-1005; published ahead of print March 20, 2009, doi:10.1124/jpet.109.152090
    • Michele T. Yip-Schneider,
    • Patrick J. Klein,
    • Sabrina C. Wentz,
    • Amer Zeni,
    • Alex Menze,
    • and C. Max Schmidt

    Resistance to Mitogen-Activated Protein Kinase Kinase (MEK) Inhibitors Correlates with Up-Regulation of the MEK/Extracellular Signal-Regulated Kinase Pathway in Hepatocellular Carcinoma Cells

    J Pharmacol Exp Ther June 2009 329:1063-1070; published ahead of print March 3, 2009, doi:10.1124/jpet.108.147306

BEHAVIORAL PHARMACOLOGY

    • William E. Fantegrossi,
    • Naoki Murai,
    • Brian Ó. Mathúna,
    • Nieves Pizarro,
    • and Rafael de la Torre

    Discriminative Stimulus Effects of 3,4-Methylenedioxymethamphetamine and Its Enantiomers in Mice: Pharmacokinetic Considerations

    J Pharmacol Exp Ther June 2009 329:1006-1015; published ahead of print March 10, 2009, doi:10.1124/jpet.109.150573
    • R. Martin-Fardon,
    • M. A. S. Baptista,
    • C. V. Dayas,
    • and F. Weiss

    Dissociation of the Effects of MTEP [3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on Conditioned Reinstatement and Reinforcement: Comparison between Cocaine and a Conventional Reinforcer

    J Pharmacol Exp Ther June 2009 329:1084-1090; published ahead of print March 3, 2009, doi:10.1124/jpet.109.151357

TOXICOLOGY

    • Tomoki Takeda,
    • Yuki Matsumoto,
    • Takayuki Koga,
    • Junpei Mutoh,
    • Yoshio Nishimura,
    • Takao Shimazoe,
    • Yuji Ishii,
    • Takumi Ishida,
    • and Hideyuki Yamada

    Maternal Exposure to Dioxin Disrupts Gonadotropin Production in Fetal Rats and Imprints Defects in Sexual Behavior

    J Pharmacol Exp Ther June 2009 329:1091-1099; published ahead of print March 10, 2009, doi:10.1124/jpet.109.151282

Errata

  • Correction to “Regulation of Somatostatin Release by Adenosine in the Mouse Stomach”

    J Pharmacol Exp Ther June 2009 329:1187

  • Correction to “Transport of Lamivudine [(-)-β-l-2′,3′-Dideoxy-3′-thiacytidine] and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors with Human Organic Cation Transporters 1, 2, and 3”

    J Pharmacol Exp Ther June 2009 329:1187

Cover image

Cover image expansion

About the cover: Imaging the dose response to dexamethasone: OVA-immunized mice received dexamethasone treatment (0.03, 0.3, and 3 mg/kg p.o.) administered before each intranasal challenge with OVA. See the article by Korideck and Peterson on page 882 of this issue.

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This Issue

June 2009; 329 (3)
Cover
  1. HIGHLIGHTED PAPERS
  2. CARDIOVASCULAR
  3. NEUROPHARMACOLOGY
  4. INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
  5. CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
  6. GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
  7. METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
  8. CELLULAR AND MOLECULAR
  9. BEHAVIORAL PHARMACOLOGY
  10. TOXICOLOGY
  11. Errata

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