Journal of Pharmacology and Experimental Therapeutics: 329 (2)

May 01, 2009; Volume 329,Issue 2

HIGHLIGHTED PAPERS

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Suppressing Inflammation Normalizes Metabolism in a Diabetic Model
Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 403;
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Glucosidase Inhibition to Improve Islet Function
Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 403;
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Carisoprodol Directly Modulates GABA Receptor Function
Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 403;

PERSPECTIVES IN PHARMACOLOGY

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Challenges in the Search for Drugs to Treat Central Nervous System Disorders
S. J. Enna and M. Williams

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 404-411; DOI: https://doi.org/10.1124/jpet.108.143420

BEHAVIORAL PHARMACOLOGY

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Altered Responses to Propofol, but Not Ketamine, in Mice Deficient in the 65-Kilodalton Isoform of Glutamate Decarboxylase
Kazuhiro Kubo, Koichi Nishikawa, Makiko Hardy-Yamada, Junko Ishizeki, Yuchio Yanagawa and Shigeru Saito

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 592-599; DOI: https://doi.org/10.1124/jpet.109.151456
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Assessment of Reinforcing Effects of Benztropine Analogs and Their Effects on Cocaine Self-Administration in Rats: Comparisons with Monoamine Uptake Inhibitors
Takato Hiranita, Paul L. Soto, Amy H. Newman and Jonathan L. Katz

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 677-686; DOI: https://doi.org/10.1124/jpet.108.145813

CARDIOVASCULAR

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Potent in Vivo Antiangiogenic Effects of GS-101 (5′-TATCCGGAGGGCTCGCCATGCTGCT-3′), an Antisense Oligonucleotide Preventing the Expression of Insulin Receptor Substrate-1
Salman Al-Mahmood, Sylvie Colin, Nada Farhat, Eric Thorin, Céline Steverlynck and Sylvain Chemtob

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 496-504; DOI: https://doi.org/10.1124/jpet.108.147496
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The Radical Trap 5,5-Dimethyl-1-Pyrroline N-Oxide Exerts Dose-Dependent Protection against Myocardial Ischemia-Reperfusion Injury through Preservation of Mitochondrial Electron Transport
Li Zuo, Yeong-Renn Chen, Levy A. Reyes, Hsin-Ling Lee, Chwen-Lih Chen, Frederick A. Villamena and Jay L. Zweier

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 515-523; DOI: https://doi.org/10.1124/jpet.108.143479
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Pharmacological Preconditioning of Mesenchymal Stem Cells with Trimetazidine (1-[2,3,4-Trimethoxybenzyl]piperazine) Protects Hypoxic Cells against Oxidative Stress and Enhances Recovery of Myocardial Function in Infarcted Heart through Bcl-2 Expression
Sheik Wisel, Mahmood Khan, M. Lakshmi Kuppusamy, I. Krishna Mohan, Simi M. Chacko, Brian K. Rivera, Benjamin C. Sun, Kálmán Hideg and Periannan Kuppusamy

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 543-550; DOI: https://doi.org/10.1124/jpet.109.150839
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Helium-Induced Early Preconditioning and Postconditioning Are Abolished in Obese Zucker Rats in Vivo
R. Huhn, A. Heinen, N. C. Weber, R. P. Kerindongo, G. T. M. L. Oei, M. W. Hollmann, W. Schlack and B. Preckel

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 600-607; DOI: https://doi.org/10.1124/jpet.108.149971
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Effect of a Synthetic Peptide Corresponding to Residues 313 to 320 of the α_IIb Subunit of the Human Platelet Integrin α_IIbβ₃ on Carotid Artery Thrombosis in Rabbits
Nikolaos D. Papamichael, Eleni M. Stathopoulou, Vassiliki D. Roussa, Loukas D. Tsironis, Anna P. Kotsia, Ruxandra-Maria Stanica, Vassilios Moussis, Vassilios Tsikaris, Christos S. Katsouras, Alexandros D. Tselepis and Lampros K. Michalis

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 634-640; DOI: https://doi.org/10.1124/jpet.108.150086
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Carbon Monoxide Rescues Mice from Lethal Sepsis by Supporting Mitochondrial Energetic Metabolism and Activating Mitochondrial Biogenesis
Steve Lancel, Sidi Mohamed Hassoun, Raphael Favory, Brigitte Decoster, Roberto Motterlini and Remi Neviere

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 641-648; DOI: https://doi.org/10.1124/jpet.108.148049
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Role of Glutaredoxin-Mediated Protein S-Glutathionylation in Cellular Nitroglycerin Tolerance
Pei-Suen Tsou, Vamsi Addanki, Jessica A. Haas, Nathaniel A. Page and Ho-Leung Fung

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 649-656; DOI: https://doi.org/10.1124/jpet.108.149997
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Red Wine Polyphenols Prevent Acceleration of Neovascularization by Angiotensin II in the Ischemic Rat Hindlimb
Allison Walter, Nelly Etienne-Selloum, David Brasse, René Schleiffer, Virgile Bekaert, Paul M. Vanhoutte, Alain Beretz and Valérie B. Schini-Kerth

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 699-707; DOI: https://doi.org/10.1124/jpet.108.148080
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Vascular Smooth Muscle-Specific Knockdown of the Noncardiac Form of the L-Type Calcium Channel by MicroRNA-Based Short Hairpin RNA as a Potential Antihypertensive Therapy
Sung W. Rhee, Joseph R. Stimers, Wenze Wang and Li Pang

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 775-782; DOI: https://doi.org/10.1124/jpet.108.148866
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Rho Kinase Inhibitors Prevent Endothelium-Dependent Contractions in the Rat Aorta
Calvin K. Y. Chan, Judith C. Mak, Ricky Y. K. Man and Paul M. Vanhoutte

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 820-826; DOI: https://doi.org/10.1124/jpet.108.148247

CELLULAR AND MOLECULAR

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Multifaceted Approach to Determine the Antagonist Molecular Mechanism and Interaction of Ibodutant ([1-(2-Phenyl-1R-{[1-(tetrahydropyran-4-ylmethyl)-piperidin-4-ylmethyl]-carbamoyl}-ethylcarbamoyl)-cyclopentyl]-amide) at the Human Tachykinin NK₂ Receptor
Stefania Meini, Francesca Bellucci, Claudio Catalani, Paola Cucchi, Alessandro Giolitti, Paolo Santicioli and Sandro Giuliani

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 486-495; DOI: https://doi.org/10.1124/jpet.108.150201
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Glycogen Synthase Kinase-3β Mediates Endoplasmic Reticulum Stress-Induced Lysosomal Apoptosis in Leukemia
Wei-Ching Huang, Yee-Shin Lin, Chia-Ling Chen, Chi-Yun Wang, Wei-Hsin Chiu and Chiou-Feng Lin

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 524-531; DOI: https://doi.org/10.1124/jpet.108.148122
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Smoke, Choline Acetyltransferase, Muscarinic Receptors, and Fibroblast Proliferation in Chronic Obstructive Pulmonary Disease
Mirella Profita, Anna Bonanno, Liboria Siena, Andreina Bruno, Maria Ferraro, Angela Marina Montalbano, Giusy Daniela Albano, Loredana Riccobono, Paola Casarosa, Michael Paul Pieper and Mark Gjomarkaj

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 753-763; DOI: https://doi.org/10.1124/jpet.108.145888
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Nonpeptidergic Allosteric Antagonists Differentially Bind to the CXCR2 Chemokine Receptor
Petra de Kruijf, Jane van Heteren, Herman D. Lim, Paolo G.M. Conti, Miranda M. C. van der Lee, Leontien Bosch, Koc-Kan Ho, Douglas Auld, Michael Ohlmeyer, Martin J. Smit, Jac C. H. M. Wijkmans, Guido J.R. Zaman, Martine J. Smit and Rob Leurs

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 783-790; DOI: https://doi.org/10.1124/jpet.108.148387

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

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Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide
Zhongfa Liu, Shujun Liu, Zhiliang Xie, Ryan E. Pavlovicz, Jiejun Wu, Ping Chen, Josephine Aimiuwu, Jiuxia Pang, Deepak Bhasin, Paolo Neviani, James R. Fuchs, Christoph Plass, Pui-Kai Li, Chenglong Li, Tim H.-M. Huang, Lai-Chu Wu, Laura Rush, Hongyan Wang, Danilo Perrotti, Guido Marcucci and Kenneth K. Chan

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 505-514; DOI: https://doi.org/10.1124/jpet.108.147934
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Use of an Anti-Vascular Endothelial Growth Factor Antibody in a Pharmacokinetic Strategy to Increase the Efficacy of Intraperitoneal Chemotherapy
Dhaval K. Shah, Beom Soo Shin, Jean Veith, Karoly Tóth, Ralph J. Bernacki and Joseph P. Balthasar

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 580-591; DOI: https://doi.org/10.1124/jpet.108.149443
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Dehydrocostuslactone, a Medicinal Plant-Derived Sesquiterpene Lactone, Induces Apoptosis Coupled to Endoplasmic Reticulum Stress in Liver Cancer Cells
Ya-Ling Hsu, Ling-Yu Wu and Po-Lin Kuo

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 808-819; DOI: https://doi.org/10.1124/jpet.108.148395

ENDOCRINE AND DIABETES

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Cilostazol Ameliorates Metabolic Abnormalities with Suppression of Proinflammatory Markers in a db/db Mouse Model of Type 2 Diabetes via Activation of Peroxisome Proliferator-Activated Receptor γ Transcription
So Youn Park, Hwa Kyoung Shin, Jeong Hyun Lee, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim and Ki Whan Hong

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 571-579; DOI: https://doi.org/10.1124/jpet.108.146456
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Chronic Administration of Voglibose, an α-Glucosidase Inhibitor, Increases Active Glucagon-Like Peptide-1 Levels by Increasing Its Secretion and Decreasing Dipeptidyl Peptidase-4 Activity in ob/ob Mice
Yusuke Moritoh, Koji Takeuchi and Masatoshi Hazama

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 669-676; DOI: https://doi.org/10.1124/jpet.108.148056

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

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Involvement of Redox-Sensitive Extracellular-Regulated Kinases in Angiotensin II-Induced Interleukin-6 Expression in Pancreatic Acinar Cells
Yuk Cheung Chan and Po Sing Leung

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 450-458; DOI: https://doi.org/10.1124/jpet.108.148353
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Interferon-γ Released by Gluten-Stimulated Celiac Disease-Specific Intestinal T Cells Enhances the Transepithelial Flux of Gluten Peptides
Michael T. Bethune, Matthew Siegel, Samuel Howles-Banerji and Chaitan Khosla

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 657-668; DOI: https://doi.org/10.1124/jpet.108.148007
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Regulation of Somatostatin Release by Adenosine in the Mouse Stomach
Gary K. Yang, Jiang-Fan Chen, Timothy J. Kieffer and Yin Nam Kwok

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 729-737; DOI: https://doi.org/10.1124/jpet.108.146050
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Prostaglandin E₂ Derived from Cyclooxygenases 1 and 2 Mediates Intestinal Epithelial Ion Transport Stimulated by the Activation of Protease-Activated Receptor 2
Jacques Q. van der Merwe, Christina L. Ohland, Christina L. Hirota and Wallace K. MacNaughton

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 747-752; DOI: https://doi.org/10.1124/jpet.108.145466
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Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease
K. Coote, H. C. Atherton-Watson, R. Sugar, A. Young, A. MacKenzie-Beevor, M. Gosling, G. Bhalay, G. Bloomfield, A. Dunstan, R. J. Bridges, J. R. Sabater, W. M. Abraham, D. Tully, R. Pacoma, A. Schumacher, J. Harris and H. Danahay

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 764-774; DOI: https://doi.org/10.1124/jpet.108.148155

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

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Treatment of Experimental Arthritis with Stealth-Type Polymeric Nanoparticles Encapsulating Betamethasone Phosphate
Tsutomu Ishihara, Tetsushi Kubota, Tesu Choi and Megumu Higaki

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 412-417; DOI: https://doi.org/10.1124/jpet.108.150276
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Involvement of Src Family Kinases in Substance P-Induced Chemokine Production in Mouse Pancreatic Acinar Cells and Its Significance in Acute Pancreatitis
Raina Devi Ramnath, Jia Sun and Madhav Bhatia

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 418-428; DOI: https://doi.org/10.1124/jpet.108.148684
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Novel Anti-Inflammatory Action of Edelfosine Lacking Toxicity with Protective Effect in Experimental Colitis
Faustino Mollinedo, Consuelo Gajate, Ana I. Morales, Esther del Canto-Jañez, Nicole Justies, Francisco Collía, Juan V. Rivas, Manuel Modolell and Antonio Iglesias

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 439-449; DOI: https://doi.org/10.1124/jpet.108.148254
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Involution of Collagen-Induced Arthritis with an Angiogenesis Inhibitor, PPI-2458
Ernest Brahn, Nathan Schoettler, Sarah Lee and Mona L. Banquerigo

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 615-624; DOI: https://doi.org/10.1124/jpet.108.148478

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

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Localization of Multidrug Resistance-Associated Protein 2 in the Nonpigmented Ciliary Epithelium of the Eye
Ryan M. Pelis, Mohammad Shahidullah, Sikha Ghosh, Miguel Coca-Prados, Stephen H. Wright and Nicholas A. Delamere

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 479-485; DOI: https://doi.org/10.1124/jpet.108.149625
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The Eighth and Ninth Transmembrane Domains in Organic Anion Transporting Polypeptide 1B1 Affect the Transport Kinetics of Estrone-3-Sulfate and Estradiol-17β-D-glucuronide
Mayuko Miyagawa, Kazuya Maeda, Akinori Aoyama and Yuichi Sugiyama

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 551-557; DOI: https://doi.org/10.1124/jpet.108.148411
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Expression Profiling of the Solute Carrier Gene Family in the Mouse Brain
Amber Dahlin, Josh Royall, John G. Hohmann and Joanne Wang

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 558-570; DOI: https://doi.org/10.1124/jpet.108.149831
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Permeability of the Blood-Brain Barrier to a Rhenacarborane
Patrick M. Hawkins, Paul A. Jelliss, Naoko Nonaka, Xiaoming Shi and William A. Banks

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 608-614; DOI: https://doi.org/10.1124/jpet.108.146878

NEUROPHARMACOLOGY

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Preclinical Evaluation of Melanin-Concentrating Hormone Receptor 1 Antagonism for the Treatment of Obesity and Depression
Donald R. Gehlert, Kurt Rasmussen, Janice Shaw, Xia Li, Paul Ardayfio, Libbey Craft, Tamer Coskun, Hong Y. Zhang, Yanyun Chen and Jeffrey M. Witkin

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 429-438; DOI: https://doi.org/10.1124/jpet.108.143362
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Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders
Renza Roncarati, Carla Scali, Thomas A. Comery, Steven M. Grauer, Suzan Aschmi, Hendrick Bothmann, Brian Jow, Dianne Kowal, Marco Gianfriddo, Cody Kelley, Ugo Zanelli, Chiara Ghiron, Simon Haydar, John Dunlop and Georg C. Terstappen

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 459-468; DOI: https://doi.org/10.1124/jpet.108.150094
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The Activation of M₁ Muscarinic Receptor Signaling Induces Neuronal Differentiation in Pyramidal Hippocampal Neurons
Kathryn L. VanDeMark, Marina Guizzetti, Gennaro Giordano and Lucio G. Costa

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 532-542; DOI: https://doi.org/10.1124/jpet.108.150128
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Role of 5-Hydroxytryptamine_2C Receptors in Ca²⁺-Dependent Ethanol Potentiation of GABA Release onto Ventral Tegmental Area Dopamine Neurons
Jonathan W. Theile, Hitoshi Morikawa, Rueben A. Gonzales and Richard A. Morrisett

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 625-633; DOI: https://doi.org/10.1124/jpet.108.147793
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Edaravone, a Free Radical Scavenger, Protects against Retinal Damage in Vitro and in Vivo
Yuta Inokuchi, Shunsuke Imai, Yoshimi Nakajima, Masamitsu Shimazawa, Makoto Aihara, Makoto Araie and Hideaki Hara

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 687-698; DOI: https://doi.org/10.1124/jpet.108.148676
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Cannabinoid CB₁ and Cholecystokinin CCK₂ Receptors Modulate, in an Opposing Way, Electrically Evoked [³H]GABA Efflux from Rat Cerebral Cortex Cell Cultures: Possible Relevance for Cortical GABA Transmission and Anxiety
Tiziana Antonelli, Maria Cristina Tomasini, Roberta Mazza, Kjell Fuxe, Silvana Gaetani, Vincenzo Cuomo, Sergio Tanganelli and Luca Ferraro

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 708-717; DOI: https://doi.org/10.1124/jpet.109.150649
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Studies of the Biogenic Amine Transporters. 13. Identification of “Agonist” and “Antagonist” Allosteric Modulators of Amphetamine-Induced Dopamine Release
Richard B. Rothman, Christina M. Dersch, Subramaniam Ananthan and John S. Partilla

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 718-728; DOI: https://doi.org/10.1124/jpet.108.149088
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Evidence for the Involvement of Dopamine Transporters in Behavioral Stimulant Effects of Modafinil
Dorota Zolkowska, Raka Jain, Richard B. Rothman, John S. Partilla, Bryan L. Roth, Vincent Setola, Thomas E. Prisinzano and Michael H. Baumann

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 738-746; DOI: https://doi.org/10.1124/jpet.108.146142
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Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine
Roger L. Papke, William R. Kem, Ferenc Soti, Gretchen Y. López-Hernández and Nicole A. Horenstein

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 791-807; DOI: https://doi.org/10.1124/jpet.108.150151
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Carisoprodol-Mediated Modulation of GABA_A Receptors: In Vitro and in Vivo Studies
Lorie A. Gonzalez, Michael B. Gatch, Cynthia M. Taylor, Cathy L. Bell-Horner, Michael J. Forster and Glenn H. Dillon

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 827-837; DOI: https://doi.org/10.1124/jpet.109.151142
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Colchicine: A Novel Positive Allosteric Modulator of the Human 5-Hydroxytryptamine_3A Receptor
A. N. de Oliveira-Pierce, R. Zhang and T. K. Machu

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 838-847; DOI: https://doi.org/10.1124/jpet.108.146522

TOXICOLOGY

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Expression and Purification of Glutathione Transferase-Small Ubiquitin-Related Modifier-Metallothionein Fusion Protein and Its Neuronal and Hepatic Protection against d-Galactose-Induced Oxidative Damage in Mouse Model
Yadong Huang, Zhijian Su, Yanmei Li, Qihao Zhang, Lejia Cui, Ye Su, Changcai Ding, Minjing Zhang, Chengli Feng, Yi Tan, Wenke Feng, Xiaokun Li and Lu Cai

Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 469-478; DOI: https://doi.org/10.1124/jpet.108.149401

EDITORIAL EXPRESSION OF CONCERN

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Editorial Expression of Concern
Journal of Pharmacology and Experimental Therapeutics May 2009, 329 (2) 848;

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Table of Contents

HIGHLIGHTED PAPERS

PERSPECTIVES IN PHARMACOLOGY

BEHAVIORAL PHARMACOLOGY

CARDIOVASCULAR

CELLULAR AND MOLECULAR

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

ENDOCRINE AND DIABETES

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

NEUROPHARMACOLOGY

TOXICOLOGY

EDITORIAL EXPRESSION OF CONCERN

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