The Journal of Pharmacology and Experimental Therapeutics is publishing an Editorial Expression of Concern regarding allegations of figure manipulation or figure duplication in several figures published in JPET. An investigation by an inquiry committee at the University of Perugia, Italy has confirmed or validated findings compatible with alleged hypotheses of electronic duplication and/or figure manipulation in the following articles:
Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Antonelli E, Roviezzo F, Morelli A, Cirino G, Wallace JL, and Fiorucci S (2006) Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels. J Pharmacol Exp Ther 316:325-335.
The figure in question is Fig. 1.
Fiorucci S, Di Lorenzo A, Renga B, Farneti S, Morelli A, and Cirino G (2004) Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-α-methyl-2-naphthaleneacetic acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO in gastric protection. J Pharmacol Exp Ther 311:1264-1271.
The figure in question is Fig. 5.
Fiorucci S, Rizzo G, Antonelli A, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski P, Morelli A, and Pellicciari R (2005) A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. J Pharmacol Exp Ther 314:584-595.
The figure in question is Fig. 6.
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Morelli A, Pruzanski M, and Pellicciari R (2005) Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor γ contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. J Pharmacol Exp Ther 315:58-68.
The figure in question is Fig. 2.
Fiorucci S, Distrutti E, Mencarelli A, Rizzo G, Di Lorenzo AR, Baldoni M, del Soldato P, Morelli A, and Wallace JL (2004) Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence. J Pharmacol Exp Ther 309:1174-1182.
The figures in question are Figs. 2 and 6.
- The American Society for Pharmacology and Experimental Therapeutics