Abstract

3-Amino-1,2,4-triazole (AT) was employed as a tracer to detect H₂O₂ within the erythrocytes of mice. H₂O₂ was clearly detected after administration of phenylhydrazine or menadione; for pamaquine, primaquine or aniline, the results were less definitive but still indicative of increased intracellular H₂O₂ levels. These results support the view that H₂O₂ toxicity plays a major role in drug-induced hemolysis of glucose-6-phosphate dehydrogenase-deficient erythrocytes.