RT Journal Article
SR Electronic
T1 <em>IN VIVO</em> GENERATION OF H<sub>2</sub>O<sub>2</sub> IN MOUSE ERYTHROCYTES BY HEMOLYTIC AGENTS
JF Journal of Pharmacology and Experimental Therapeutics
JO J Pharmacol Exp Ther
FD American Society for Pharmacology and Experimental Therapeutics
SP 139
OP 143
VO 147
IS 1
A1 Cohen, Gerald
A1 Hochstein, Paul
YR 1965
UL http://jpet.aspetjournals.org/content/147/1/139.abstract
AB 3-Amino-1,2,4-triazole (AT) was employed as a tracer to detect H2O2 within the erythrocytes of mice. H2O2 was clearly detected after administration of phenylhydrazine or menadione; for pamaquine, primaquine or aniline, the results were less definitive but still indicative of increased intracellular H2O2 levels. These results support the view that H2O2 toxicity plays a major role in drug-induced hemolysis of glucose-6-phosphate dehydrogenase-deficient erythrocytes. The Williams &amp; Wilkins Comapny